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G6895

Supelco

Glafenine

analytical standard

Synonym(s):

1-Glyceryl N-(7-chloro-4-quinolyl)anthranilate

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About This Item

Empirical Formula (Hill Notation):
C19H17ClN2O4
CAS Number:
3820-67-5
Molecular Weight:
372.80
EC Number:
223-315-7
MDL number:
MFCD00079326
UNSPSC Code:
41116107
PubChem Substance ID:
329799956

grade

analytical standard

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

OCC(O)COC(=O)c1ccccc1Nc2ccnc3cc(Cl)ccc23

InChI

1S/C19H17ClN2O4/c20-12-5-6-14-17(7-8-21-18(14)9-12)22-16-4-2-1-3-15(16)19(25)26-11-13(24)10-23/h1-9,13,23-24H,10-11H2,(H,21,22)

InChI key

GWOFUCIGLDBNKM-UHFFFAOYSA-N

Gene Information

human ... PTGS1(5742) , PTGS2(5743)

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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C Moesch et al.
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies, 31(5), 329-333 (1993-05-01)
Glaphenine is an analgesic drug derived from anthranilic acid. We report the analytical procedures for stone analysis in three cases of common bile duct stones containing glaphenic acid, which developed in arthrosic patients treated for 13.7 +/- 5 years with
Bo Wen et al.
Drug metabolism and disposition: the biological fate of chemicals, 39(9), 1511-1521 (2011-06-02)
Glafenine (Privadol; 2,3-dihydroxypropyl 2-[(7-chloro-4-quinolinyl) amino]benzoate) is a non-narcotic analgesic agent widely used for the treatment of pains of various origins. Severe liver toxicity and a high incidence of anaphylaxis were reported in patients treated with glafenine, eventually leading to its
Renaud Robert et al.
Molecular pharmacology, 77(6), 922-930 (2010-03-05)
Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR) gene, which encodes a cAMP-activated anion channel expressed in epithelial cells. The most common mutation Delta Phe508 leads to protein misfolding, retention by the endoplasmic reticulum
A Davido et al.
La Revue de medecine interne, 10(2), 113-117 (1989-03-01)
Glafenine-induced shock. Seven cases. Glafenine is a widely prescribed analgesic drug, and shock is one of its severe side-effects. We report six documented and one highly probable cases of such accidents. From these seven cases and a review of the
M Fernandez-Rivas et al.
Annals of allergy, 71(6), 515-518 (1993-12-01)
Anthranilic acid derivatives are a group of nonsteroidal antiinflammatory drugs that include glafenine and fenamates. We report a woman who had immediate adverse reactions to glafenine and meclofenamate sodium. Skin prick and intradermal tests were performed with solutions of glafenine
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