MABT108
Anti-TNF-alpha induced protein 6 (TSG-6) Antibody, clone NG3
clone NG3, from mouse
Synonym(s):
Tumor necrosis factor-inducible gene 6 protein, TNF-stimulated gene 6 protein, TSG-6, Tumor necrosis factor alpha-induced protein 6, TNF alpha-induced protein 6
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
NG3, monoclonal
species reactivity
human, mouse
technique(s)
ELISA: suitable
western blot: suitable
isotype
IgG2bκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
General description
Tumor Necrosis Factor-alpha (TNF-alpha), also known as TSG-6, is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells and certain other target cells. The mature form of human TNF-alpha has 157 amino acid residues. TNF-alpha induced protein 6 may be involved in cell-cell and cell-matrix interactions during normal inflammatory responses and during tumorigenesis.
Specificity
Published to react with human TSG-6 (Nagyeri, G., et al. (2011). JBC. PMID: 21566135).
Immunogen
Epitope: Unknown
GST-tagged recombinant protein corresponding to mouse TSG-6.
Application
Detect TNF-alpha induced protein 6 (TSG-6) using this Anti-TNF alpha Antibody, clone NG3 validated for use in WB, ELISA. This TNF alpha antibody has been tested in Human and Mouse.
ELISA: A previous lot of this antibody was used in capture ELISA to demonstrate a typical standard curve for measuring TSG6 from normal (naïve) serum.
Western Blot Analysis: A previous lot of this antibody was show to detect human or mouse samples (Nagyeri, G., et al. (2011). JBC. PMID: 21566135).
Western Blot Analysis: A previous lot of this antibody was show to detect human or mouse samples (Nagyeri, G., et al. (2011). JBC. PMID: 21566135).
Research Category
Cell Structure
Cell Structure
Research Sub Category
ECM Proteins
ECM Proteins
Quality
Evaluated by Western Blot in mouse ovary tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected TSG-6 in 10 µg of mouse ovary tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected TSG-6 in 10 µg of mouse ovary tissue lysate.
Target description
~29 kDa observed.
An uncharacterized band appears at ~50 kDa in some lysates.
An uncharacterized band appears at ~50 kDa in some lysates.
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
Mouse ovary tissue lysate
Mouse ovary tissue lysate
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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F E Watt et al.
Osteoarthritis and cartilage, 28(3), 324-333 (2020-01-07)
Surgical knee joint distraction (KJD) leads to clinical improvement in knee osteoarthritis (OA) and also apparent cartilage regeneration by magnetic resonance imaging. We investigated if alteration of the joint's mechanical environment during the 6 week period of KJD was associated
Fiona E Watt et al.
Arthritis & rheumatology (Hoboken, N.J.), 68(9), 2129-2140 (2016-03-19)
To investigate whether molecules found to be up-regulated within hours of surgical joint destabilization in the mouse are also elevated in the analogous human setting of acute knee injury, how this molecular response varies between individuals, and whether it is
Chiara Di Santo et al.
International journal of molecular sciences, 24(6) (2023-03-30)
The identification of novel targets to modulate the immune response triggered by cerebral ischemia is crucial to promote the development of effective stroke therapeutics. Since tumour necrosis factor (TNF)-α-stimulated gene 6 (TSG-6), a hyaluronate (HA)-binding protein, is involved in the
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