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700042P

Avanti

4β-hydroxycholesterol-d7

Avanti Research™ - A Croda Brand

Synonym(s):

cholest-5-ene-3b,4b-diol(d7)

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About This Item

Empirical Formula (Hill Notation):
C27H39O2D7
CAS Number:
1246302-80-6
Molecular Weight:
409.70
UNSPSC Code:
12352100
NACRES:
NA.25

description

cholest-5-ene-3,4-diol-d7

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (700042P-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

shipped in

dry ice

storage temp.

−20°C

InChI

1S/C27H46O2/c1-17(2)7-6-8-18(3)20-11-12-21-19-9-10-23-25(29)24(28)14-16-27(23,5)22(19)13-15-26(20,21)4/h10,17-22,24-25,28-29H,6-9,11-16H2,1-5H3/t18-,19+,20-,21+,22+,24+,25-,26-,27-/m1/s1/i1D3,2D3,17D

InChI key

CZDKQKOAHAICSF-BZNWTYAPSA-N

General description

4β-hydroxycholesterol (4β-HC) is a catabolic product of cholesterol metabolism mediated by the enzyme cytochrome P450 family 3 subfamily A member 4 (CYP3A4). 4β-hydroxycholesterol-d7 is the deuterated form of 4β-hydroxycholesterol.

Application

4β-hydroxycholesterol-d7 has been used:
  • as an internal standard to spike plasma samples ultra-high-pressure liquid,chromatography–tandem mass spectrometry (UHPLC-MS/MS) analysis
  • to spike serum samples for mass spectrometry measurements
  • as an internal standard for the quantification of human colon biopsies samples using HPLC-MS

Biochem/physiol Actions

4β-hydroxycholesterol (4β-HC) may function as a liver X receptor ligand. The levels of 4β-HC are elevated in dextran sulfate induced colitis along with other oxysterols and it may promote colon inflammation.

Packaging

5 mL Amber Glass Screw Cap Vial (700042P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mahmoud Hasan et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1033-1034, 193-199 (2016-08-28)
Cytochrome P450 3A (CYP) enzymes are involved in the elimination of many drugs and are known to be regulated by several environmental factors. Thus, it was the aim of this study to develop and validate an analytical method allowing estimation
Owein Guillemot-Legris et al.
Journal of Crohn's & colitis, 13(2), 218-229 (2018-10-09)
Inflammatory bowel diseases [IBD] represent a challenging health issue with a complex aetiology involving genetic and environmental parameters. Although our understanding of the pathophysiology of IBD has improved, much remains to be explored. In this context, bioactive lipids, more specifically
Sarah J Woolsey et al.
Basic & clinical pharmacology & toxicology, 118(4), 284-291 (2015-09-25)
Due to high basal interindividual variation in cytochrome P450 3A (CYP3A) activity and susceptibility to drug interactions, there has been interest in the application of efficient probe drug phenotyping strategies, as well as endogenous biomarkers for assessment of in vivo

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