- Synthesis and characterization of new 1-hydroxy-2-pyridinethione derivatives: Their lead complexes and efficacy in the treatment of acute lead poisoning in rats.
Synthesis and characterization of new 1-hydroxy-2-pyridinethione derivatives: Their lead complexes and efficacy in the treatment of acute lead poisoning in rats.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) (2017-10-03)
Manal H Al Khabbas, Samah A Ata, Kamal I Abu-Dari, Maha F Tutunji, Mohammad S Mubarak
PMID28965578
ZUSAMMENFASSUNG
A number of new mono- and dihydroxypyridinethione ligands have been synthesized via reaction of dimethylamine and amino acid esters with the active amide obtained from the reaction of 1-hydroxy-2-pyridinethione-4-carboxylic acid (1) and 1,1'-carbonyldiimidazole in DMF. Moreover, the lead complexes of these new ligands were also prepared. Structures of the newly synthesized compounds have been confirmed by different spectroscopic methods such as IR,
MATERIALIEN