- The novel gene fad104, containing a fibronectin type III domain, has a significant role in adipogenesis.
The novel gene fad104, containing a fibronectin type III domain, has a significant role in adipogenesis.
FEBS letters (2004-11-06)
Kei Tominaga, Chiharu Kondo, Yoshikazu Johmura, Makoto Nishizuka, Masayoshi Imagawa
PMID15527760
ZUSAMMENFASSUNG
A novel gene named fad104 (factor for adipocyte differentiation-104), whose expression level quickly increased in the early stage of adipogenesis, was isolated and characterized. The deduced amino acid sequence of fad104 revealed the possible presence of a fibronectin type III domain and transmembrane domain. The expression of fad104 was detected in adipocyte differentiable 3T3-L1 cells but not observed in the non-adipogenic cell line NIH-3T3. Moreover, the ability of 3T3-L1 cells to differentiate declined with the knockdown of fad104 by RNA interference, strongly indicating that fad104 functions as a positive regulator of adipogenesis.