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Effect of spironolactone on p-nitrophenol glucuronidation in isolated rat hepatocytes.

Experientia (1983-05-15)
E E Guibert, L S Morisoli, J A Monti, E A Rodriguez Garay
ZUSAMMENFASSUNG

The effect of spironolactone (SP) on p-nitrophenol (PNP) glucuronidation was studied in isolated rat hepatocytes with appropriate viability conditions. A significant increase of protein concentration and PNP glucuronidation was found in the hepatocytes from SP-treated rats. Increased enzyme activity apparently was related to the SP dose. The results favor the conclusion that SP may induce PNP glucuronidation in the hepatocyte.

MATERIALIEN
Produktnummer
Marke
Produktbeschreibung

Sigma-Aldrich
4-Nitrophenyl β-D-Glucuronid, ≥98% (TLC)
Sigma-Aldrich
4-Nitrophenyl β-D-Glucuronid, ≥99.0% (TLC)