Concise total synthesis of (-)-8-epigrosheimin.

Concise total synthesis of (-)-8-epigrosheimin.

Organic letters (2011-06-17)

Haishen Yang, Yuzhe Gao, Xiaoxiao Qiao, Longguan Xie, Xiaohua Xu

ZUSAMMENFASSUNG

A highly efficient route was developed to synthesize (-)-8-epigrosheimin in four steps from aldehyde 2 based on a substrate-controlled method. The key steps of the synthesis included (1) a stereo- and regioselective allylation addition, (2) an intramolecular translactonization, and (3) an aldehyde-ene cyclization.

MATERIALIEN

Produktnummer

Marke

Produktbeschreibung

124931

Sigma-Aldrich

(R)-(−)-Carvon, 98%

435759

Sigma-Aldrich

(S)-(+)-Carvon, 96%

W224901

Sigma-Aldrich