- Unprecedented Cu(I)-catalyzed microwave-assisted three-component coupling of a ketone, an alkyne, and a primary amine.
Unprecedented Cu(I)-catalyzed microwave-assisted three-component coupling of a ketone, an alkyne, and a primary amine.
Organic letters (2010-05-06)
Olga P Pereshivko, Vsevolod A Peshkov, Erik V Van der Eycken
PMID20441203
ZUSAMMENFASSUNG
An efficient, microwave-assisted Cu(I)-catalyzed one-pot coupling of a ketone, an alkyne, and a primary amine (KA(2) coupling) is described, giving access to secondary propargylamines.