- Potent and highly selective kappa opioid receptor agonists incorporating chroman- and 2,3-dihydrobenzofuran-based constraints.
Potent and highly selective kappa opioid receptor agonists incorporating chroman- and 2,3-dihydrobenzofuran-based constraints.
Bioorganic & medicinal chemistry letters (2005-10-06)
Guo-Hua Chu, Minghua Gu, Joel A Cassel, Serge Belanger, Thomas M Graczyk, Robert N DeHaven, Nathalie Conway-James, Mike Koblish, Patrick J Little, Diane L DeHaven-Hudkins, Roland E Dolle
PMID16203140
ZUSAMMENFASSUNG
Two novel chemical classes of kappa opioid receptor agonists, chroman-2-carboxamide derivatives and 2,3-dihydrobenzofuran-2-carboxamide derivatives, were synthesized. These agents exhibited high and selective affinity for the kappa opioid receptor.
MATERIALIEN