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T6764

Sigma-Aldrich

Triprolidin -hydrochlorid

≥99%

Synonym(e):

(E)-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride, trans-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride

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1 G
CHF 40.90
5 G
CHF 145.00

About This Item

Empirische Formel (Hill-System):
C19H22N2 · HCl
CAS-Nummer:
6138-79-0
Molekulargewicht:
314.85
MDL-Nummer:
MFCD00039044
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24277808
NACRES:
NA.77

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Assay

≥99%

Löslichkeit

alcohol: soluble 1 in 1.5 of solvent
chloroform: soluble 1 in less than 1 of solvent
H2O: soluble 50 mg/mL, clear, colorless to yellow

Ersteller

GlaxoSmithKline

Lagertemp.

2-8°C

SMILES String

CC(C=C1)=CC=C1/C(C2=NC=CC=C2)=C\CN3CCCC3.Cl

InChI

1S/C19H22N2.ClH/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21;/h2-3,6-12H,4-5,13-15H2,1H3;1H/b18-11+;

InChIKey

WYUYEJNGHIOFOC-NWBUNABESA-N

Angaben zum Gen

human ... HRH1(3269)

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Anwendung

Triprolidine has been used as a H1 histaminergic inhibitor to study its effect on long-term potentiation (LTP) in tuberomammillary nucleus (TMN) neurons[1].

Biochem./physiol. Wirkung

H1 histamine receptor antagonist.

Leistungsmerkmale und Vorteile

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Angaben zur Herstellung

Triprolidine hydrochloride is soluble in water at 50 mg/ml and yields a clear, colorless to yellow solution. It is also soluble in alcohol (1 in 1.5 of solvent) and chloroform (1 in less than 1 of solvent).

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Preisangaben

D1069

Desloratadin, powder, ≥98% (HPLC)

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000280443
0000267560
0000190869
SLBQ6732V
MKBS0509V

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Adnan Manassra et al.
Journal of pharmaceutical and biomedical analysis, 51(4), 991-993 (2009-12-04)
An HPLC method using UV detection is proposed for the simultaneous determination of pseudophedrine hydrochloride, codeine phosphate, and triprolidine hydrochloride in liquid formulation. C18 column (250mmx4.0mm) is used as the stationary phase with a mixture of methanol:acetate buffer:acetonitrile (85:5:10, v/v)
Feifei Feng et al.
The Journal of pharmacy and pharmacology, 72(4), 507-518 (2020-02-08)
Ketotifen (K) and its active metabolite norketotifen (N) exist as optically active atropisomers. They both have antihistaminic and anti-inflammatory properties but the S-atropisomer of N (SN) causes less sedation than K and RN in rodents. This study investigated whether this
Ashok K Shakya et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(32), 4071-4078 (2009-11-21)
A highly efficient, selective and specific method for simultaneous quantitation of triprolidine and pseudoephedrine in human plasma by liquid chromatography-ion trap-tandem mass spectrometry coupled with electro spray ionization (LC-ESI-ion trap-tandem MS) has been validated and successfully applied to a clinical
Sang-Chul Shin et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 61(1-2), 14-19 (2005-07-12)
The bioavailability of triprolidine from the ethylene vinyl acetate (EVA) matrix system containing polyoxyethylene-2-oleyl ether was studied to determine the feasibility of enhanced transdermal delivery of triprolidine in rabbits. The antihistamine effects were also confirmed to determine the percutaneous absorption
Karunya K Kandimalla et al.
International journal of pharmaceutics, 302(1-2), 133-144 (2005-08-18)
Hydroxyzine and triprolidine have both been reported to reach the CNS following nasal administration. The objective of this study was to investigate their in vitro permeation across bovine olfactory mucosa in order to further characterize the biological and physicochemical parameters
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