SML2963

8-Azaguanin

≥98% (HPLC)

• Synonym(e): 2-Amino-6-hydroxy-8-azapurin, Guanazolo
• Empirische Formel (Hill-System): C₄H₄N₆O
• CAS-Nummer: 134-58-7
• Molekulargewicht: 152.11
• UNSPSC Code: 12352200
• Beilstein/REAXYS Number: 171098
• MDL number: MFCD00056937
• NACRES: NA.21
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• mp: >300 °C (lit.)
• solubility: DMSO: 2 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: NC1=Nc2[nH]nnc2C(=O)N1
• InChI: 1S/C4H4N6O/c5-4-6-2-1(3(11)7-4)8-10-9-2/h(H4,5,6,7,8,9,10,11)
• InChI key: LPXQRXLUHJKZIE-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

8-Azaguanine is a triazole-antimetabolite that displays varies pharmacological effects including anticancer, antiviral and antifungal. It is easily incorporated into ribonucleic acids including rRNA and tRNA. 8-Azaguanine appears to alter mRNA splicing in SF3B1 mutant cells. 8-Azaguanine novel immunomodulatory drug (IMiD) that significantly increases the cytotoxicity of NK cells.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H302
• Sicherheitshinweise: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable