SML0924

ML167

≥98% (HPLC)

• Synonym(e): 5-[4-[[(5-Methyl-2-furanyl)methyl]amino]-6-quinazolinyl]-2-furanmethanol, CID 44968231, NCGC00188654
• Empirische Formel (Hill-System): C₁₉H₁₇N₃O₃
• CAS-Nummer: 1285702-20-6
• Molekulargewicht: 335.36
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: off-white to gray-brown
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: −20°C
• SMILES string: N(Cc4[o]c(cc4)C)c1ncnc2c1cc(cc2)c3[o]c(cc3)CO
• InChI: 1S/C19H17N3O3/c1-12-2-4-14(24-12)9-20-19-16-8-13(3-6-17(16)21-11-22-19)18-7-5-15(10-23)25-18/h2-8,11,23H,9-10H2,1H3,(H,20,21,22)
• InChI key: ROCFOIBAEVAOLQ-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

ML167 is a selective inhibitor of of Cdc2-like kinase 4 (Clk4).

ML167 is the first highly selective inhibitor of of Cdc2-like kinase 4 (Clk4) with an IC₅₀ of 136 nM for Clk4, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B, and minimal activity against a panel of other kinases tested. The Cdc2-like kinases (Clk′s) and the dual-specificity tyrosine phosphorylation-regulated kinases (Dyrk′s) are involved in regulation of gene splicing. The Cdc2-like kinases phosphorylate the serine/arginine-rich (SR) proteins, a major component of the spliceosome.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H302
• Sicherheitshinweise: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable