SML0683

JNJ-40418677

≥98% (HPLC)

• Synonym(e): 2-(S)-(3,5-Bis(4-(trifluoromethyl)phenyl)phenyl)-4-methylpentanoic acid
• Empirische Formel (Hill-System): C₂₆H₂₂F₆O₂
• CAS-Nummer: 1146594-87-7
• Molekulargewicht: 480.44
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 15 mg/mL, clear
• Ersteller: Johnson & Johnson
• Relevante Krankheit(en): Alzheimer′s disease
• Lagertemp.: 2-8°C

Beschreibung

Biochem./physiol. Wirkung

JNJ-40418677 is a γ-secretase modulator that selectively blocks γ-site cleavage of the APP without affecting processing of Notch. In human neuroblastoma cells and rat primary neuronal cultures, JNJ-40418677 blocked secretion of Aβb42 (IC₅₀ = 20 nM), with no affects on total Ab concentration, Notch signaling or COX activity. In vivo experiments showed that JNJ-40418677 dose dependently inhibited Aβ42 accumulation in the brain while promoting an increase in Aβ38.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H300,H413
• P-Sätze: P264 - P270 - P273 - P301 + P310 - P405 - P501
• Gefahreneinstufungen: Acute Tox. 2 Oral - Aquatic Chronic 4
• Lagerklassenschlüssel: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable