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S9652

Safrol

≥97%

Synonym(e):

4-Allyl-1,2-methylendioxy-benzol, 5-Allyl-1,3-benzodioxol

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Empirische Formel (Hill-System):
C10H10O2
CAS-Nummer:
Molekulargewicht:
162.19
UNSPSC Code:
12352200
NACRES:
NA.25
PubChem Substance ID:
EC Number:
202-345-4
Beilstein/REAXYS Number:
136380
MDL number:
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vapor pressure

1 mmHg ( 63.8 °C)

Quality Segment

assay

≥97%

color

yellow

refractive index

n20/D 1.537 (lit.)

bp

232-234 °C (lit.)

mp

11.2 °C (lit.)

density

1.095 g/mL at 25 °C (lit.)

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

SMILES string

C=CCc1ccc2OCOc2c1

InChI

1S/C10H10O2/c1-2-3-8-4-5-9-10(6-8)12-7-11-9/h2,4-6H,1,3,7H2

InChI key

ZMQAAUBTXCXRIC-UHFFFAOYSA-N

General description

Safrole is used as a counter irritant and for treating parasitic infections.

Application

Safrole has been used to investigate the role of aldehyde dehydrogenase 3A1 (ALDH3A1) in conferring cisplatin resistance to head and neck squamous cell carcinoma (HNSCC).

Biochem/physiol Actions

Safrole is one of the vital food‐borne phytotoxins. It is present in various natural products such as spices including anise, basil, nutmeg and pepper. It exhibits cytotoxic effect in human tongue squamous carcinoma SCC‐4 cells by promoting apoptosis via mitochondria‐ and caspase‐dependent signal pathways.
Safrol ist eine natürlich vorkommende, genotoxische Verbindung, die in Sassafraswurzel und Betel (Areca)-Pfriem gefunden wird. Es ist ein Hepatocarcinogen und Safrol-DNA-Addukte wurden auch beim Mundkrebs von Betelnuss Konsumenten beobachtet. Die Metaboliten von Safrol bilden Addukte mit der DNA und lösen chromasomale Aberrationen und Schwesterchromatidaustausch aus.

Other Notes

Hauptbestandteil von Sassafrasöl

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Dieser Artikel
594423739383179000
assay

≥97%

assay

97%

assay

97%

assay

97%

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

application(s)

-

application(s)

-

application(s)

-

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

100

color

yellow

color

-

color

-

color

-

refractive index

n20/D 1.537 (lit.)

refractive index

n20/D 1.5000 (lit.)

refractive index

n20/D 1.497

refractive index

n20/D 1.549 (lit.)

vapor pressure

1 mmHg ( 63.8 °C)

vapor pressure

-

vapor pressure

-

vapor pressure

-


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pictograms

Health hazardExclamation mark

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B - Muta. 2 - Skin Irrit. 2

Lagerklasse

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

212.0 °F - closed cup

flash_point_c

100 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter



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Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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