RAB0659

Human FOLR1 / Folate Receptor Alpha ELISA Kit

• UNSPSC-Code: 41116158
• NACRES: NA.84

Eigenschaften

• Speziesreaktivität: human
• Verpackung: kit of 96 wells (12 strips x 8 wells)
• Methode(n): ELISA: suitable
• Aufnahme: sample type cell culture supernatant(s); sample type plasma; sample type serum
• assay range: inter-assay cv: <12%; intra-assay cv: <10%; sensitivity: 0.1 ng/mL; standard curve range: 0.102-25 ng/mL
• Nachweisverfahren: colorimetric
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Angaben zum Gen: human ... FOLR1(2348)

Beschreibung

Allgemeine Beschreibung

The antibody pair provided in this kit recognizes human Folate Receptor Alpha.
The folate receptor 1 (FOLR1) gene is mapped to human chromosome 11q13.4.[1] The gene codes for a glycosylphosphatidylinositol protein that is attached to cell membranes.[2] Folr1 is expressed in placenta, kidney tubules and choroid plexus.[2]

Anwendung

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

Biochem./physiol. Wirkung

Folate receptor 1 (FOLR1) plays a vital role in folate transport across the blood–brain barrier through the choroid plexus.[3] It is also essential for neural tube closure during embryogenesis.[3] Mutation in the gene leads to the development of cerebral folate deficiency in a few families.[1][3] Overexpression of the gene has been observed in some epithelial malignancies including medulloblastoma, ovarian, lung and breast carcinomas. FOLR1 acts as a potential biomarker and therapeutic target for medulloblastoma.[2]

Kit-Komponenten auch einzeln erhältlich

• RABTMB3 ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)
• RABSTOP3 ELISA Stop Solution (Item I)
• RABWASH4 20X Wash Buffer (Item B)

Sicherheitshinweise

• Piktogramme: GHS05
• Signalwort: Warning
• H-Sätze: H290
• P-Sätze: P234 - P390
• Gefahreneinstufungen: Met. Corr. 1
• Lagerklassenschlüssel: 8B - Non-combustible corrosive hazardous materials
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable