P4670

Propafenon -hydrochlorid

• Synonym(e): 1-[2-(2-Hydroxy-3-(propylamino)propoxy)phenyl]-3-phenyl-1-propanone hydrochloride
• Empirische Formel (Hill-System): C₂₁H₂₇NO₃ · HCl
• CAS-Nummer: 34183-22-7
• Molekulargewicht: 377.90
• EG-Nummer: 251-867-9
• MDL-Nummer: MFCD00079243
• UNSPSC-Code: 41116107
• PubChem Substanz-ID: 24278636
• NACRES: NA.77

Eigenschaften

• Form: powder
• Ersteller: Abbott
• Lagertemp.: 2-8°C
• SMILES String: Cl[H].CCCNCC(O)COc1ccccc1C(=O)CCc2ccccc2
• InChI: 1S/C21H27NO3.ClH/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17;/h3-11,18,22-23H,2,12-16H2,1H3;1H
• InChIKey: XWIHRGFIPXWGEF-UHFFFAOYSA-N
• Angaben zum Gen: human ... ABCB1(5243) , ADRB1(153) , ADRB2(154) , ADRB3(155) , CYP1A2(1544) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

Beschreibung

Allgemeine Beschreibung

Propafenone hydrochloride is a calcium antagonist.[1] It functions as a Na⁺ and K⁺ channel blocker.[2] It might be used to treat patients with systemic hypertension.[3] Propafenone hydrochloride is associated with bradycardia and bronchospasms. It is metabolized in the liver.[4] Propafenone hydrochloride is used to treat ventricular arrhythmias.[2]

Anwendung

Propafenone hydrochloride has been used in the isolation of cardiomyocytes.[5]

Biochem./physiol. Wirkung

Blocks hKv1.5 and ATP-sensitive K⁺ channels; class 1C antiarrhythmic agent that is also an antagonist at β adrenergic receptors.

Leistungsmerkmale und Vorteile

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3