P0040

PP1

≥98% (HPLC), PTK inhibitor, powder

• Synonym(e): 4-Amino-5-(methylphenyl)-7-(t-butyl)pyrazolo-(3,4-d)pyrimidine
• Empirische Formel (Hill-System): C₁₆H₁₉N₅
• CAS-Nummer: 172889-26-8
• Molekulargewicht: 281.36
• UNSPSC Code: 12352200
• PubChem Substance ID: 329819992
• NACRES: NA.77
• MDL number: MFCD01076570
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Produktname: PP1, ≥98% (HPLC)
• assay: ≥98% (HPLC)
• form: powder
• color: white to off-white
• solubility: DMSO: >20 mg/mL
• storage temp.: room temp
• SMILES string: Cc1ccc(cc1)-c2nn(c3ncnc(N)c23)C(C)(C)C
• InChI: 1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19)
• InChI key: ZVPDNRVYHLRXLX-UHFFFAOYSA-N

Beschreibung

Application

PP1 has been used as:

• an inhibitor of sarcoma (Src) family kinases (SFK) like hematopoietic cell kinase (hck) and fyn[1]
• a selective Src tyrosine kinase inhibitor in hippocampal neuronal cultures to test its effect on neurite growth[2]
• a Src-kinase blocker to test its effect on brimonidine (BMD)-induced phosphorylation in extracellular signal-activated kinases(ERK1/2)[3]

Biochem/physiol Actions

PP1 is a potent and selective Src family protein tyrosine kinase inhibitor.

PP1 is a pyrazolopyrimidine compound[4] that acts as a competitive inhibitor of adenosine triphosphate (ATP) binding.[5] It also inhibits protein tyrosine kinase (PTK6)[4] and may be useful in the therapeutic management of PTK6 positive based breast cancer malignancy.[4]

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral