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K3769

Sigma-Aldrich

KW-3902

≥98% (HPLC)

Synonym(e):

1,3-dipropyl-8-(3-noradamantyl)xanthine, 8-(Hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,7-dihydro-1,3-dipropyl-1H-purine-2,6-dione, MK-7418, Rolofylline

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About This Item

Empirische Formel (Hill-System):
C20H28N4O2
CAS-Nummer:
136199-02-5
Molekulargewicht:
356.46
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329817141
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

solid

Löslichkeit

DMSO: 20 mg/mL
soluble

Lagertemp.

2-8°C

SMILES String

CCCN1C(=O)N(CCC)c2[nH]c(nc2C1=O)[C@]34C[C@H]5C[C@H](C[C@@H]3C5)C4

InChI

1S/C20H28N4O2/c1-3-5-23-16-15(17(25)24(6-4-2)19(23)26)21-18(22-16)20-10-12-7-13(11-20)9-14(20)8-12/h12-14H,3-11H2,1-2H3,(H,21,22)/t12-,13+,14-,20-

InChIKey

PJBFVWGQFLYWCB-OYEQCZOJSA-N

Biochem./physiol. Wirkung

KW-3902 is an A1 adenosine receptor antagonist and is over 800 fold more selective for an A1 receptor versus the A2A receptor.

Leistungsmerkmale und Vorteile

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

H-Sätze

H413

P-Sätze

P273 - P501

Gefahreneinstufungen

Aquatic Chronic 4

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Adriaan A Voors et al.
Journal of the American College of Cardiology, 57(19), 1899-1907 (2011-05-07)
This study sought to assess the effects of rolofylline on renal function in patients with acute heart failure (AHF) and renal dysfunction randomized in PROTECT (Placebo-Controlled Randomized Study of the Selective A(1) Adenosine Receptor Antagonist Rolofylline for Patients Hospitalized With
Piotr Ponikowski et al.
European journal of heart failure, 12(11), 1238-1246 (2010-09-09)
The direct effects of adenosine A1 receptor antagonists on haemodynamic parameters in patients with acute heart failure (HF) remain largely unknown. We evaluated the haemodynamic effects of the AA(1)RA rolofylline in 59 HF patients with concomitant renal impairment (estimated creatinine
Marco Metra et al.
European journal of heart failure, 12(5), 499-507 (2010-03-17)
Dyspnoea is the most common symptom leading to hospitalization for acute heart failure (AHF). Its early and persistent relief is an important goal of therapy, but little is known about its course, determinants, and prognostic significance. In a post hoc
Mustafa M Dohadwala et al.
Cardiovascular therapeutics, 26(4), 276-286 (2008-11-28)
Acute decompensated heart failure (ADHF), generally related to signs and symptoms of volume overload, is one the most common reasons for hospitalization in the United States. Recently, it has been observed that the majority of patients with ADHF have baseline
Gad Cotter et al.
Journal of cardiac failure, 14(8), 631-640 (2008-10-18)
Rolofylline, an adenosine A(1) receptor antagonist, facilitates diuresis and preserves renal function in patients with acute heart failure (AHF) with renal impairment. Although not powered around any specific hypothesis, this pilot study was designed to identify an efficacious dose while
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