I6256

2-Iminothiolan -hydrochlorid

≥98% (TLC), powder

• Synonym(e): 2-Thiolanimin -hydrochlorid, 2IT, Dihydro-2(3H)-thiophenimin -hydrochlorid, Traut’s Reagens
• Empirische Formel (Hill-System): C₄H₇NS · HCl
• CAS-Nummer: 4781-83-3
• Molekulargewicht: 137.63
• UNSPSC Code: 12352100
• NACRES: NA.21
• PubChem Substance ID: 24896086
• MDL number: MFCD00039013
• Beilstein/REAXYS Number: 3620079
• Assay: ≥98% (TLC)
• Form: powder
• Solubility: H₂O: 100 mg/mL

Eigenschaften

• Quality Segment: 200
• assay: ≥98% (TLC)
• form: powder
• impurities: ≤5% Free sulfhydryl groups
• mp: 198-201 °C (lit.)
• solubility: H₂O: 100 mg/mL
• functional group: thioether
• storage temp.: 2-8°C
• SMILES string: N=C1SCCC1.Cl
• InChI: 1S/C4H7NS.ClH/c5-4-2-1-3-6-4;/h5H,1-3H2;1H
• InChI key: ATGUDZODTABURZ-UHFFFAOYSA-N

Beschreibung

General description

2-Iminothiolane hydrochloride (2-IT.HCl), a protein modification reagent, is commonly employed to attach thiol groups to proteins and peptides. Raman spectroscopic analysis of hair keratin fibers modified with 2-IT.HCl showed the formation of new disulfide groups.

Application

Thiolating reagent for primary amines. Reacts at pH 7-10 by amidine bond to present free sulfhydryl. Useful in preparation of disulfide and/or thioether linked conjugates.

2-Iminothiolane hydrochloride has been used in the synthesis of thiolated PEG (poly(ethylene glycol). It may be used to synthesize PLA-SH (polyethylene glycol-thiol) and PLA-PEG-SH (polyethylene glycol–polylactic acid-thiol).

Other Notes

Note that the amidine linkage preserves original primary amine positive charge. Incorporates a five atom linker.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• Gefahrencodes: H301
• Sicherheitshinweise: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Gloves, type N95 (US)