H0786

Heregulin-β, EGF Domain human

≥80% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous glycerol solution

• Synonym(e): HRG-β
• MDL-Nummer: MFCD01867052
• UNSPSC-Code: 12352202
• NACRES: NA.32

Eigenschaften

• Biologische Quelle: human
• Qualitätsniveau: 200
• Rekombinant: expressed in E. coli
• Assay: ≥80% (SDS-PAGE)
• Form: buffered aqueous glycerol solution
• Mol-Gew.: 185 kDa
• Verpackung: pkg of 100 μg
• Lagerbedingungen: avoid repeated freeze/thaw cycles
• UniProt-Hinterlegungsnummer: Q02297
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Angaben zum Gen: human ... NRG1(3084)

Beschreibung

Allgemeine Beschreibung

Truncated human sequence (amino acids 178-241) corresponding to the EGF domain and purified as a GST-fusion protein, cleaved with thrombin.

Biochem./physiol. Wirkung

Growth factor ligand for ErbB3 and ErbB4 receptor tyrosine kinases. The binding of HRG results in receptor dimerization and receptor trans-autophosphorylation. The phosphorylated receptors recruit cellular signaling proteins, initiating signaling pathways.

Physikalische Form

Solution in phosphate buffered saline containing 30% glycerol.

Hinweis zur Analyse

Stimulates tyrosine phosphorylation of the ErbB-3/HER-3 receptor.

The biological activity is measured by its ability to activate the c-ErbB3/HER-3 receptor in treated MCF-7 cells.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable