F1293

Finasterid

≥98% (HPLC), powder

• Synonym(e): N-(2-methyl-2-propyl)-3-oxo-4-aza-5α-androst-1-en-17β-carboxamid, N-tert.-Butyl-3-oxo-4-aza-5α-androst-1-en-17β-carboxamid, MK-906
• Empirische Formel (Hill-System): C₂₃H₃₆N₂O₂
• CAS-Nummer: 98319-26-7
• Molekulargewicht: 372.54
• MDL-Nummer: MFCD00869737
• UNSPSC-Code: 41116107
• PubChem Substanz-ID: 24724479
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: soluble >20 mg/mL
• Lagertemp.: room temp
• SMILES String: [H][C@@]12CC[C@@]3([H])[C@]4([H])CC[C@H](C(=O)NC(C)(C)C)[C@@]4(C)CC[C@]3([H])[C@@]1(C)C=CC(=O)N2
• InChI: 1S/C23H36N2O2/c1-21(2,3)25-20(27)17-8-7-15-14-6-9-18-23(5,13-11-19(26)24-18)16(14)10-12-22(15,17)4/h11,13-18H,6-10,12H2,1-5H3,(H,24,26)(H,25,27)/t14-,15-,16-,17+,18+,22-,23+/m0/s1
• InChIKey: DBEPLOCGEIEOCV-WSBQPABSSA-N
• Angaben zum Gen: human ... HSD3B1(3283) , SRD5A1(6715) , SRD5A2(6716) ; rat ... Hsd3b1(360348) , Srd5a1(24950) , Srd5a2(64677)

Beschreibung

Anwendung

Finasteride has been used:

• as a component of L-15 media to investigate the effects of finasteride exposure on brain, liver and testis tissues
• in culture medium to treat tumor cells in vitro
• as a positive control to treat benign prostatic hyperplasia (BPH)
• to examine its effect on structural and molecular biology on the ventral prostate of senile mice

Biochem./physiol. Wirkung

Finasteride can reduce serum and scalp dihydrotestosterone (DHT) by preventing the transformation of testosterone to DHT. It is usually used to manage benign prostate hyperplasia and pattern hair loss in male. Finasteride possesses androgen-distracting properties.

Selektiver 5a-Reduktasehemmer; antiandrogen.

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Danger
• H-Sätze: H302,H360FD
• P-Sätze: P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313
• Gefahreneinstufungen: Acute Tox. 4 Oral - Repr. 1B
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Faceshields, Gloves