Fusidinsäure

Name: Fusidinsäure
Brand: SIGMA

Antibiotic

Synonym(e):

Ramycin

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Über diesen Artikel

Empirische Formel (Hill-System):

C₃₁H₄₈O₆

CAS-Nummer:

6990-06-3

Molekulargewicht:

516.71

NACRES:

NA.77

PubChem Substance ID:

57654174

UNSPSC Code:

12352106

EC Number:

230-256-0

MDL number:

MFCD00865135

Technischer Dienst

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Eigenschaften

Produktname

Fusidinsäure,

Quality Segment

200

storage temp.

2-8°C

SMILES string

[H][C@@]12CC[C@@]3(C)[C@@]([H])([C@H](O)C[C@@]4([H])\C([C@H](C[C@]34C)OC(C)=O)=C(/CC\C=C(\C)C)C(O)=O)[C@@]1(C)CC[C@@H](O)[C@H]2C

InChI

1S/C31H48O6/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36)/b26-20-/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-/m0/s1

InChI key

IECPWNUMDGFDKC-MZJAQBGESA-N

Beschreibung

Application

Fusidic acid has been used:

as a standard in thin-layer chromatography (TLC)-densitometric method
to study its ability to bind to human serum albumin
as an antibiotic in combination with tannic acid to determine minimum inhibitory concentrations (MIC) in methicillin-resistant Staphylococcus aureus (MRSA)

Biochem/physiol Actions

Fusidic acid is a tetracyclic triterpenoid with antibiotic activity against Gram-positive bacteria. It is derived from Fusidium coccineum. It shows its activity against anaerobes, corynebacterial, Nocardia, and Neisseria species. Fusidic acid exhibits therapeutic effects against Staphylococcal infections, skin infections.

Suppresses nitric oxide lysis of pancreatic islet cells. Inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA.

Suppresses nitric oxide lysis of pancreatic islet cells; inhibits protein synthesis in prokaryotes.