D4526

Doxepin -hydrochlorid

≥98% (GC), norepinephrine uptake inhibitor, powder

• Synonym(e): 11-(3-Dimethylaminopropyliden)-6,11-dihydrodibenz[b,e]oxepin -hydrochlorid
• Empirische Formel (Hill-System): C₁₉H₂₁NO · HCl
• CAS-Nummer: 1229-29-4
• Molekulargewicht: 315.84
• NACRES: NA.77
• PubChem Substance ID: 24278093
• UNSPSC Code: 12352200
• EC Number: 214-966-8
• MDL number: MFCD00079135
• Assay: ≥98% (GC)
• Form: powder

Eigenschaften

• Produktname: Doxepin -hydrochlorid, ~85% E-isomer basis, ≥98% (GC), 15% Z-isomer basis, powder
• Quality Segment: 200
• assay: ≥98% (GC)
• form: powder
• composition: Z-isomer, 15% , E-isomer, ~85%
• color: white to off-white
• solubility: 1 M HCl: 50 mg/mL, H₂O: soluble
• originator: Boehringer Ingelheim
• SMILES string: Cl[H].CN(C)CC\C=C1/c2ccccc2COc3ccccc13
• InChI: 1S/C19H21NO.ClH/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19;/h3-6,8-12H,7,13-14H2,1-2H3;1H/b17-11+;
• InChI key: MHNSPTUQQIYJOT-SJDTYFKWSA-N
• Gene Information: human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133), HRH1(3269), HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)

Beschreibung

General description

Doxepin is used to treat chronic idiopathic urticaria, chronic pain and anxiety. Doxepin exhibits antiserotonergic properties.

Biochem/physiol Actions

Tricyclic antidepressant that is a more potent inhibitor of norepinephrine uptake than of serotonin uptake; antagonist at H₁ histamine, muscarinic cholinergic, and α-adrenoreceptors.

Features and Benefits

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Other Notes

Mixture of cis- and trans-isomers

Sicherheitshinweise

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges