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D4317

Sigma-Aldrich

3,5-Diiodothyropropionic acid

Synonym(e):

DITPA

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About This Item

Empirische Formel (Hill-System):
C15H12I2O4
CAS-Nummer:
1158-10-7
Molekulargewicht:
510.06
MDL-Nummer:
MFCD00045945
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24893861

Lagertemp.

2-8°C

SMILES String

OC(=O)CCc1cc(I)c(Oc2ccc(O)cc2)c(I)c1

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Biochem./physiol. Wirkung

DITPA, an analog of L-thyroxine, has inotropic but not chronotropic effects on heart muscle. It also stimulates myocardial angiogenesis after infarction by interaction with integrin αvཪ3 at the cell surface.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

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Reza Arsanjani et al.
Journal of molecular and cellular cardiology, 51(4), 506-511 (2011-01-11)
Thyroid hormone has unique properties affecting the heart, and the vasculature and cholesterol metabolism. There is interest in using thyromimetic agents as possible treatment options for heart failure based on data demonstrating the ability of these agents to improve systolic
M A Hassan Talukder et al.
American journal of physiology. Heart and circulatory physiology, 300(2), H702-H711 (2010-12-07)
There is emerging evidence that treatment with thyroid hormone (TH) can improve postischemic cardiac function. 3,5-Diiodothyropropionic acid (DITPA), a TH analog, has been proposed to be a safer therapeutic agent than TH because of its negligible effects on cardiac metabolism
Abdelrahman A Abohashem-Aly et al.
The Journal of surgical research, 171(2), 379-385 (2011-06-11)
Thyroid hormone can have positive effects on the cardiovascular system but its therapeutic potential is limited secondary to its adverse effects. DITPA (3,5-diiodothyroproprionic acid) is a synthetic thyroid hormone analog with positive inotropic effects similar to thyroid hormone but with
Najah R Hadi et al.
BMC nephrology, 12, 70-70 (2011-12-27)
Acute renal failure (ARF) is an important clinical problem with a high mortality and morbidity. One of the primary causes of ARF is ischemia/reperfusion (I/R). Inflammatory process and oxidative stress are thought to be the major mechanisms causing I/R. MK-886
Peter H Spooner et al.
Journal of cardiovascular pharmacology, 44(4), 453-459 (2004-09-30)
This study was designed to determine if the thyroid hormone analog 3,5 diiodothyropropionic acid (DITPA), now in clinical trials for heart failure, alters endothelial function after myocardial infarction (MI). Three weeks after MI, adult Sprague-Dawley rats were randomly assigned to
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