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C5174

Sigma-Aldrich

7-Chlor-5-(4-chlorphenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-on

≥98% (TLC)

Synonym(e):

4′-Chlorodiazepam

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About This Item

Empirische Formel (Hill-System):
C16H12Cl2N2O
CAS-Nummer:
14439-61-3
Molekulargewicht:
319.19
Beilstein:
685202
MDL-Nummer:
MFCD00043406
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24892765
NACRES:
NA.77

Qualitätsniveau

200

Assay

≥98% (TLC)

Form

powder

Arzneimittelkontrolle

regulated under CDSA - not available from Sigma-Aldrich Canada

Löslichkeit

2-hydroxypropyl-β-cyclodextrin: insoluble
H2O: insoluble

SMILES String

O=C1CN=C(C2=CC=C(Cl)C=C2)C3=CC(Cl)=CC=C3N1C

InChI

1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3

InChIKey

PUMYFTJOWAJIKF-UHFFFAOYSA-N

Angaben zum Gen

rat ... Tspo(24230)

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Verwandte Kategorien

Anwendung

4′-Chlorodiazepam has been used as a translocator protein ligand in mitochondrial functional studies. It has also been used to investigate its protective effects on glucose deprived T98G astrocyte cell lines.

Biochem./physiol. Wirkung

4′-Chlorodiazepam (Ro5-4864) is a potent selective ligand for the mitochondrial translocator protein 18kDa (TSPO), formerly known as the peripheral benzodiazepine receptor (PBR). Ro5-4864 does not bind to GABA(A) receptors and lacks typical benzodiazepine effects, but has been found to be neuroprotective in several studies.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302

Gefahreneinstufungen

Acute Tox. 4 Oral

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

4?-Chlorodiazepam protects mitochondria in T98G astrocyte cell line from glucose deprivation
Baez E, et al.
Neurotoxicity Research, 32(2), 163-171 (2017)
A TSPO ligand prevents mitochondrial sterol accumulation and dysfunction during myocardial ischemia-reperfusion in hypercholesterolemic rats
Musman J, et al.
Biochemical Pharmacology, 142, 87-95 (2017)
Guillaume Bouyer et al.
Blood, 118(8), 2305-2312 (2011-07-29)
Plasmodium falciparum relies on anion channels activated in the erythrocyte membrane to ensure the transport of nutrients and waste products necessary for its replication and survival after invasion. The molecular identity of these anion channels, termed "new permeability pathways" is
L Veenman et al.
Current molecular medicine, 12(4), 398-412 (2012-02-22)
The mitochondrial 18 kDa Translocator Protein (TSPO) was first detected by its capability to bind benzodiazepines in peripheral tissues and later also in glial cells in the brain, hence its previous most common name peripheral benzodiazepine receptor (PBR). TSPO has
Irene Marginedas-Freixa et al.
International journal of molecular sciences, 19(10) (2018-10-13)
Two main isoforms of the Translocator Protein (TSPO) have been identified. TSPO1 is ubiquitous and is mainly present at the outer mitochondrial membrane of most eukaryotic cells, whereas, TSPO2 is specific to the erythroid lineage, located at the plasma membrane
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