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Fortfahren mit
C0378
Chloramphenicol
≥98% (HPLC)
Synonym(e):
D(−)-threo-2,2-Dichlor-N-[β-hydroxy-α-(hydroxymethyl)-β-(4-nitrophenyl)-ethyl]-acetamid, D-(−)-threo-2-Dichloracetamido-1-(4-nitrophenyl)-1,3-propandiol, D-threo-2,2-Dichlor-N-[β-hydroxy-α-(hydroxymethyl)-4-nitrophenethyl]-acetamid, Chloromycetin
Größe auswählen
| Ihnen/SKU | Verfügbarkeit | Preis |
|---|---|---|
5 g | Warenkorb auf Verfügbarkeit prüfen | CHF 43.60 |
25 g | Warenkorb auf Verfügbarkeit prüfen | CHF 77.00 |
100 g | Warenkorb auf Verfügbarkeit prüfen | CHF 264.00 |
500 g | Warenkorb auf Verfügbarkeit prüfen | CHF 885.00 |
1 kg | Warenkorb auf Verfügbarkeit prüfen | CHF 1’470.00 |
Über diesen Artikel
Quality Segment
assay
≥98% (HPLC)
form
powder or crystals
pKa
5.5
mp
149-153 °C (lit.)
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria, mycobacteria, mycoplasma
mode of action
protein synthesis | interferes
storage temp.
room temp
SMILES string
OC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc(cc1)[N+]([O-])=O
InChI
1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1
InChI key
WIIZWVCIJKGZOK-RKDXNWHRSA-N
Gene Information
human ... CYP1A2(1544)
General description
Application
Chloramphenicol wird als bakteriostatisches, nicht starkes Antibiotikum verwendet. Es wird für die Selektion bzw. das Wachstum positiver Bakterienzellen eingesetzt.
Biochem/physiol Actions
Resistenzmechanismus: Die Verwendung von Chloramphenicol-Acetyltransferase führt zur Acetylierung und Inaktivierung des Produkts.
Antimikrobielles Spektrum: Es handelt sich um ein Breitbandantibiotikum gegen grampositive und gramnegative Bakterien, das vor allem in der Augenheilkunde und in der Tiermedizin eingesetzt wird.
Preparation Note
Other Notes
Disclaimer
1 of 1
Dieser Artikel | |||
|---|---|---|---|
| mode of action protein synthesis | interferes | mode of action protein synthesis | interferes | mode of action - | mode of action - |
| antibiotic activity spectrum Gram-negative bacteria, mycobacteria, Gram-positive bacteria, mycoplasma | antibiotic activity spectrum viruses | antibiotic activity spectrum - | antibiotic activity spectrum - |
| Quality Level 200 | Quality Level 200 | Quality Level - | Quality Level - |
| assay ≥98% (HPLC) | assay 97.0-103.0% | assay - | assay - |
| form powder or crystals | form crystalline | form - | form powder |
| storage temp. room temp | storage temp. 2-8°C | storage temp. - | storage temp. 2-8°C |
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signalword
Danger
hcodes
Hazard Classifications
Carc. 2 - Eye Dam. 1 - Repr. 2
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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How can I determine the shelf life / expiration / retest date of this product?
1 answer-
Helpful?
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Was the pKa determined experimentally, or is it based on data from the literature? If the value is from the literature, please provide the source.
1 answer-
The value comes from literature. Two references that cite this value are:
Georgeta-Simona Stan, Irinel Adriana Badea, Hassan Y. Aboul-Enein, HPLC Method for Quantification of Five Compounds in a Parenteral Form Used in Treatment of Companion Animals, Journal of Chromatographic Science, Volume 54, Issue 9, 17 October 2016, Pages 1567–1572, https://doi.org/10.1093/chromsci/bmw105
Engesland, A., Škalko-Basnet, N., & Flaten, G. E. (2016). In vitro models to estimate drug penetration through the compromised stratum corneum barrier. Drug Development and Industrial Pharmacy, 42(11), 1742–1751. https://doi.org/10.3109/03639045.2016.1171334
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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