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B5311

Sigma-Aldrich

Biperiden -hydrochlorid

≥98% (HPLC), powder

Synonym(e):

1-(5-Bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-(1-piperidinyl)propan-1-ol hydrochloride, Akineton, Akinophyl

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About This Item

Empirische Formel (Hill-System):
C21H30ClNO
CAS-Nummer:
1235-82-1
Molekulargewicht:
347.92
EG-Nummer:
214-976-2
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329773254

Assay

≥98% (HPLC)

Form

powder

Farbe

off-white

Löslichkeit

DMSO: >20 mg/mL
H2O: insoluble

Ersteller

Abbott

SMILES String

Cl[H].OC(CCN1CCCCC1)(C2CC3CC2C=C3)c4ccccc4

InChI

1S/C21H29NO.ClH/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17;/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2;1H

InChIKey

RDNLAULGBSQZMP-UHFFFAOYSA-N

Angaben zum Gen

human ... CHRM1(1128)

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Biochem./physiol. Wirkung

Biperiden hydrochloride is antiparkinsonian; non-selective muscarinic receptor antagonist. It is used for the adjunctive treatment of all forms of Parkinson′s Disease (postencephalitic, idiopathic, and arteriosclerotic); also commonly used to improve parkinsonian signs and symptoms related to antipsychotic drug therapy. LD50 in rats 750 mg/kg; in dogs 340 mg/kg.

Leistungsmerkmale und Vorteile

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302

Gefahreneinstufungen

Acute Tox. 4 Oral

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Marina S Zacarias et al.
Neuroscience letters, 513(2), 129-131 (2012-02-18)
It is well-known that cocaine dependence is a public health issue, and several studies stress the need to look for new and more effective treatments. Although the mesolimbic dopamine (DA) system, which originates in the ventral tegmental area (VTA) and
Use of anticholinergic drugs and worsening of pemphigus foliaceus in a patient with bipolar disorder.
Lúcio Botelho-Nogueira et al.
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 33(4), 412-413 (2011-12-23)
Elmorsy Khaled et al.
Talanta, 87, 40-45 (2011-11-22)
The construction and performance characteristics of Biperiden (BP) polyvinyl chloride (PVC) electrodes are described. Different methods for electrode fabrication are tested including; incorporation of BP-ion pairs (BP-IPs), incorporation of ion pairing agents, or soaking the plain electrode in BP-ion pairs
Anna C Ramos et al.
Behavioural brain research, 231(1), 213-216 (2012-04-04)
Cocaine addiction is a public health issue in many countries, stressing the need for more effective treatments. As all drugs of abuse, cocaine acts on the brain reward system, increasing dopamine (DA) levels. Other neurotransmitters such as acetylcholine (ACh) are
[Current classifications of dystonies, treatment strategy].
Z A Zalialova
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 113(3), 85-89 (2013-04-25)
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Artikel

Muscarinic Acetylcholine Receptors

Muscarinic acetylcholine receptors mediate acetylcholine actions in CNS and non-nervous tissues, crucial for cell signaling.

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