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A2126

Sigma-Aldrich

Acetyl-β-Methylcholin-Bromid

≥99%

Synonym(e):

Methacholine bromide

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About This Item

Lineare Formel:
CH3CO2CH(CH3)CH2N(CH3)3Br
CAS-Nummer:
333-31-3
Molekulargewicht:
240.14
EG-Nummer:
206-372-2
MDL-Nummer:
MFCD00011816
UNSPSC-Code:
12352103
PubChem Substanz-ID:
24890626
NACRES:
NA.25

Assay

≥99%

Form

powder

mp (Schmelzpunkt)

147-149 °C (lit.)

Lagertemp.

−20°C

SMILES String

[Br-].CC(C[N+](C)(C)C)OC(C)=O

InChI

1S/C8H18NO2.BrH/c1-7(11-8(2)10)6-9(3,4)5;/h7H,6H2,1-5H3;1H/q+1;/p-1

InChIKey

MMVPLEUBMWUYIB-UHFFFAOYSA-M

Angaben zum Gen

human ... CHRM3(1131)

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Anwendung

Acetyl-β-methylcholine bromide (methylcholine bromide, methacholine bromide, Mch), a muscarinic acetylcholine receptor agonist, may be used in studies that involve the indentification, characterization and mechanism of action of muscarinic acetylcholine receptors. Mch may be used as a reference material in procedures used to detect or quantify its presence.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

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David C Hornigold et al.
British journal of pharmacology, 138(7), 1340-1350 (2003-04-25)
1. We have examined possible mechanisms of cross-talk between the G(q/11)-linked M(3) muscarinic acetylcholine (mACh) receptor and the G(i/o)-linked M(2) mACh receptor by stable receptor coexpression in Chinese hamster ovary (CHO) cells. A number of second messenger (cyclic AMP, Ins(1,4,5)P(3))
John T Fisher et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 18(6), 711-713 (2004-02-24)
The presence of multiple muscarinic acetylcholine receptor (mAChR) subtypes in the heart and lung, combined with the lack of mAChR subtype-selective ligands, have complicated the task of identifying the mAChR subtypes mediating cardiac slowing (bradycardia) and airway narrowing (bronchoconstriction) due
M J van der Schans et al.
Journal of chromatography. A, 735(1-2), 387-393 (1996-05-31)
Solutions of histamine and methacholine bromide in different matrices for diagnostic purposes were analyzed for stability and quality control using capillary electrophoresis. Histamine (2,[4-imidazolyl]ethylamine) [CAS No. 51-45-6] was determined using a 0.1 M Tris-borate buffer of pH 8.3 with 5.10(-5)
Anyue Yin et al.
British journal of pharmacology, 175(16), 3394-3406 (2018-06-03)
Development of combination therapies has received significant interest in recent years. Previously, a two-receptor one-transducer (2R-1T) model was proposed to characterize drug interactions with two receptors that lead to the same phenotypic response through a common transducer pathway. We applied
M Yamada et al.
Nature, 410(6825), 207-212 (2001-03-10)
Members of the muscarinic acetylcholine receptor family (M1-M5) have central roles in the regulation of many fundamental physiological functions. Identifying the specific receptor subtype(s) that mediate the diverse muscarinic actions of acetylcholine is of considerable therapeutic interest, but has proved
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