A0606

Aurothioglukose

≥96% (titration)

• Synonym(e): Aurothioglucose
• Empirische Formel (Hill-System): C₆H₁₁AuO₅S · xH₂O
• CAS-Nummer: 12192-57-3
• Molekulargewicht: 392.18 (anhydrous basis)
• EG-Nummer: 235-365-7
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24724383
• NACRES: NA.77

Eigenschaften

• Assay: ≥96% (titration)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to beige
• Löslichkeit: H₂O: 5 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: O.OC[C@H]1O[C@H](S[Au])[C@H](O)[C@@H](O)[C@@H]1O
• InChI: 1S/C6H12O5S.Au.H2O/c7-1-2-3(8)4(9)5(10)6(12)11-2;;/h2-10,12H,1H2;;1H2/q;+1;/p-1/t2-,3-,4+,5-,6-;;/m1../s1
• InChIKey: SGVIEHTYEMEDRR-PKXGBZFFSA-M

Beschreibung

Anwendung

Aurothioglucose hydrate has been used in redox stress survival assay in human cell lines and for inducing obese phenotype in mice.

Biochem./physiol. Wirkung

Aurothioglucose, a gold compound used clinically to treat rheumatoid arthritis, has recently been found to be a potent PKCiota-Par6 interaction inhibitor, with an IC₅₀ approximately 1 μM. Disruption of this interaction disrupts a rac1 signaling pathway that is required for transformed growth in non-small-cell lung cancer.

Leistungsmerkmale und Vorteile

This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Danger
• H-Sätze: H317,H334
• P-Sätze: P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313
• Gefahreneinstufungen: Resp. Sens. 1 - Skin Sens. 1
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Faceshields, Gloves