87128

Tetracyclin

98.0-102.0% (HPLC)

• Synonym(e): Tetracycline HCL, Tetracycline Monohydrochloride
• Empirische Formel (Hill-System): C₂₂H₂₄N₂O₈ · xH₂O
• CAS-Nummer: 60-54-8
• Molekulargewicht: 444.43 (anhydrous basis)
• Beilstein: 2230417
• EG-Nummer: 200-481-9
• MDL-Nummer: MFCD00151232
• UNSPSC-Code: 51284017
• PubChem Substanz-ID: 57653229
• NACRES: NA.85

Eigenschaften

• Biologische Quelle: synthetic
• Assay: 98.0-102.0% (HPLC)
• Form: powder or crystals
• Farbe: faint yellow to dark yellow
• mp (Schmelzpunkt): 172-174 °C (dec.)
• Wirkungsspektrum von Antibiotika: Gram-negative bacteria; Gram-positive bacteria
• Wirkungsweise: protein synthesis | interferes
• Lagertemp.: 2-8°C
• SMILES String: CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O
• InChI: 1S/C22H24N2O8/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30)/t9-,10-,15-,21+,22-/m0/s1
• InChIKey: OFVLGDICTFRJMM-WESIUVDSSA-N
• Angaben zum Gen: human ... CYP1A2(1544) , TERT(7015)

Beschreibung

Allgemeine Beschreibung

Chemical structure: tetracycline

Biochem./physiol. Wirkung

Mode of Action: Tetracycline passively diffuses through proin channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells. The inhibitory effects can be reversed by washing, suggesting that it is the reversibly bound antibiotic, and not the irreversibly bound drug, that is responsible for antibacterial action.

Mode of Resistance: The effects are inactivated via a loss of cell wall permeability.

Antimicrobial spectrum: Includes a wide range of antimicrobial activity against gram-positive and gram-negative bacteria.

Verpackung

25g, 100g

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place.Hygroscopic. Light sensitive. Keep in a dry place.

Sicherheitshinweise

• Piktogramme: GHS08,GHS07,GHS09
• Signalwort: Warning
• H-Sätze: H302,H361fd,H411
• P-Sätze: P202 - P264 - P273 - P280 - P301 + P312 - P308 + P313
• Gefahreneinstufungen: Acute Tox. 4 Oral - Aquatic Chronic 2 - Repr. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves