405M-1

FOXA1 (2F83) Mouse Monoclonal Antibody

• NACRES: NA.41
• UNSPSC Code: 12352203
• Conjugate: unconjugated
• Clone: 2F83, monoclonal
• Application: IHC (p)
• Citations: 2

Eigenschaften

• biological source: mouse
• Quality Segment: 100, 500
• conjugate: unconjugated
• antibody form: culture supernatant
• antibody product type: primary antibodies
• clone: 2F83, monoclonal
• description: For In Vitro Diagnostic Use in Select Regions (See Chart)
• form: buffered aqueous solution
• species reactivity: human
• packaging: vial of 0.1 mL concentrate (405M-14), vial of 0.5 mL concentrate (405M-15), bottle of 1.0 mL predilute (405M-17), vial of 1.0 mL concentrate (405M-16), bottle of 7.0 mL predilute (405M-18)
• manufacturer/tradename: Cell Marque^®
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
• isotype: IgG1κ
• control: breast carcinoma
• shipped in: wet ice
• storage temp.: 2-8°C
• visualization: nuclear
• Gene Information: human ... FOXA1(3169)

Beschreibung

General description

Forkhead box A1 (FOXA1), also known as hepatocyte nuclear factor 3 alpha(HNF3a), is a transcription factor expressed in normal breast ductal epithelium and other epithelium in different organs, such as lung, pancreas, bladder, prostate, and colon. It has been reported to co-express with ER in breast carcinoma, predominantly in luminal subtype A.[1][2] FOXA1 expression has been identified in 42% - 75% of invasive carcinoma of the breast.[1][2] Of the FOXA1-positive breast invasive carcinomas, 83% were comprised of ER+/PR+/Her2+ luminal A subtype.[1] The results indicate that anti-FOXA1 is useful in the sub-classification of breast carcinoma.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Analysis Note

IVD

IVD

IVD

RUO

Other Notes

FOXA1 Positive Control Slides, Product No. 405S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

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Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany