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258024

Sigma-Aldrich

α-Tocopherol

≥95.5%

Synonym(e):

(±)-α-Tocopherol, DL-α-Tocopherol, Vitamin E

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5 G
CHF 37.40
100 G
CHF 184.00
500 G
CHF 738.00

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5 G
CHF 37.40
100 G
CHF 184.00
500 G
CHF 738.00

About This Item

Empirische Formel (Hill-System):
C29H50O2
CAS-Nummer:
10191-41-0
Molekulargewicht:
430.71
Beilstein:
94012
EG-Nummer:
233-466-0
MDL-Nummer:
MFCD00006848
UNSPSC-Code:
12352205
eCl@ss:
34058016
PubChem Substanz-ID:
57648149
NACRES:
NA.28

CHF 37.40

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Biologische Quelle

synthetic

Qualitätsniveau

200

Assay

≥95.5%

Form

liquid

Methode(n)

HPLC: suitable

Farbe

faint brown to brown
 yellow to very dark yellow

Dichte

0.950 g/mL at 20 °C (lit.)

Anwendung(en)

cell analysis

Lagertemp.

2-8°C

SMILES String

CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(O)c(C)c(C)c2O1

InChI

1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3

InChIKey

GVJHHUAWPYXKBD-UHFFFAOYSA-N

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Allgemeine Beschreibung

α-Tocopherol is the active form of vitamin E.[1] It functions as an hydroperoxyl radical scavenger and protects the organism from oxidative damage. α-Tocopherol plays a crucial role in cell signalling and regulating immune responses.[2] α-Tocopherol deficiency is associated with abetalipoproteinemia, cystic fibrosis and celiac disease.[1] It has antiproliferative effects.[3] It inhibits arsenite-induced damage of human fibroblasts.[4]

Anwendung

α-Tocopherol has been used:
  • as a standard to determine its concentration by reverse-phase high-performance liquid chromatography[5][6]
  • to study its rescue effects on chlorine dioxide (ClO2) cytotoxicity[7]
  • to assess its protective effects on acetaminophen (APAP)-mediated liver damage[8]

Biochem./physiol. Wirkung

Tocopherols (TCP) (vitamin E) are a series (α, β, γ and δ) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by homo sapiens. Various isofroms and analogues of tocopherol have opposing and differentiated regulatory activities in vivo.

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08168

Timestrip Plus™ 8 °C

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H317

Gefahreneinstufungen

Skin Sens. 1

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Persönliche Schutzausrüstung

Eyeshields, Gloves

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
MKCW5964
MKCX1479
0000422457
0000311457
0000356109

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Effects of vitamin E on reproductive protection in pregnant mice infected with Pseudorabies Virus (PRV) via regulating expression of Toll-like receptors (TLRs) and cytokine balance
Wu D, et al.
Journal of nutritional science and vitaminology, 56(6), 353-363 (2010)
Glycosphingolipids Prevent APAP and HMG-CoA Reductase Inhibitors-mediated Liver Damage: A Novel Method for ?Safer Drug? Formulation that Prevents Drug-induced Liver Injury
Mizrahi M, et al.
Journal of clinical and translational hepatology, 6(2), 1-8 (2018)
Medical Countermeasures?Chelation Therapy
Handbook of Arsenic Toxicology, 589-626 (2015)
Sarawoot Palipoch et al.
BMC complementary and alternative medicine, 14, 111-111 (2014-03-29)
cis-Diammineplatinum (II) dichloride (cisplatin) is the important anti-cancer agent useful in treatment of various cancers. Unfortunately, it can produce unwanted side effects in various tissues, including the liver. The present study investigated the possible protective role of curcumin and α-tocopherol
Nutritional deficiencies and syndromes associated with alcoholism
Textbook of Clinical Neurology (Third Edition), 897-917 (2007)
Alle zugehörigen Dokumente anzeigen

Artikel

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. Could you please provide the concentration of this product (mg/ml)?

    1 answer

    1. This product is a neat or pure liquid and has not been diluted. This material has a density of 0.950 g/mL and a molecular weight of 430.71 g/mol. The minimum purity is 95.5%, thus the molarity will vary slightly from lot to lot. The molarity can range from 2.11M (95.5%) to 2.20M (100%).

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