04573

Thiamin -hydrochlorid

tested according to Ph. Eur.

• Synonym(e): Thiamio hydrochloridum, Aneurin -hydrochlorid, Vitamin B₁ -hydrochlorid
• Empirische Formel (Hill-System): C₁₂H₁₇ClN₄OS · HCl
• CAS-Nummer: 67-03-8
• Molekulargewicht: 337.27
• NACRES: NA.26
• PubChem Substance ID: 329747946
• eCl@ss: 34058006
• UNSPSC Code: 12352209
• EC Number: 200-641-8
• MDL number: MFCD00012780
• Beilstein/REAXYS Number: 3851771

Eigenschaften

• biological source: synthetic
• Quality Segment: 200
• agency: tested according to Ph. Eur.
• assay: 98.5-101.0% anhydrous basis
• form: solid
• mp: 250 °C (dec.) (lit.)
• solubility: alcohol: soluble 1 gm in 100 ml (95%), alcohol: soluble 1 gm in 315 ml (Absolute), glycerol: soluble 1 gm in 18 ml, water: soluble 1 g/mL, benzene: insoluble, chloroform: insoluble, diethyl ether: insoluble, hexane: insoluble, methanol: very soluble, propylene glycol: soluble
• storage temp.: 2-8°C
• SMILES string: CC1=NC(N)=C(C[N+]2=CSC(CCO)=C2C)C=N1.Cl.[Cl-]
• InChI: 1S/C12H17N4OS.2ClH/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;;/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);2*1H/q+1;;/p-1
• InChI key: DPJRMOMPQZCRJU-UHFFFAOYSA-M

Beschreibung

Application

Thiamine hydrochloride has been used as a keratin salts medium supplement for culturing log-phase fungus. It has also been used as a supplement of VB medium the minimal medium of Vogel and Bonner.

Biochem/physiol Actions

Thiamine hydrochloride is a cheap, non-toxic and efficient catalyst for the synthesis of amidoalkyl naphthols. It inhibits the production of shikonin derivatives by suspension cultures of Lithospermum erythrorhizon. Additionally, thiamine hydrochloride addition to apple juice concentrates reduces its patulin content.

Thiamine hydrochloride is a hydrochloride salt form of thiamine (Vitamin B₁). It is crucial for aerobic metabolism, cell growth, transmission of nerve impulses and acetylcholine synthesis.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H319
• pcodes: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Lagerklasse: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)