573121

SMER28

A cell-permeable quinazoline compound that augments the cytostatic effects of Rapamycin and acts as an autophagy stimulator both in mammalian cultures in vitro and in a Drosophila melanogaster HD model in vivo.

• Synonym(e): SMER28, (6-Bromo-4-allylamino)quinazoline, Small- Molecule Enhancer of Rapamycin-28, Autophagy Inducer II, (6-Bromo-4-allylamino)quinazoline, Small-Molecule Enhancer of Rapamycin-28, Autophagy Inducer II
• Empirische Formel (Hill-System): C₁₁H₁₀BrN₃
• CAS-Nummer: 307538-42-7
• Molekulargewicht: 264.12
• MDL-Nummer: MFCD02166825
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95% (HPLC)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: pale yellow
• Löslichkeit: ethanol: 10 mg/mL; DMSO: 100 mg/mL
• Versandbedingung: ambient
• Lagertemp.: 2-8°C
• InChI: 1S/C11H10BrN3/c1-2-5-13-11-9-6-8(12)3-4-10(9)14-7-15-11/h2-4,6-7H,1,5H2,(H,13,14,15)
• InChIKey: BCPOLXUSCUFDGE-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

A cell-permeable quinazoline compound that augments the cytostatic effects of Rapamycin (Cat. Nos. 553210 and 553211) in Saccharomyces cerevisiae and acts as an autophagy stimulator both in mammalian cultures in vitro and in a Drosophila melanogaster HD model in vivo. Although SMER28 and Rapamycin do exhibit additive effects on the clearance of cellular autophagy substrates, SMER28 functions independently of Rapamycin by presumably acting on celluar target(s) downstream of the Rapamycin/FKBP12 target, mTOR.

A cell-permeable quinazoline compound that augments the cytostatic effects of Rapamycin (Cat. Nos. 553210 and 553211) in Saccharomyces cerevisiae and acts as an autophagy stimulator both in mammalian cultures in vitro and in a Drosophila melanogaster HD model in vivo. Although SMER28 and Rapamycin do exhibit additive effects on the clearance of cellular autophagy substrates, SMER28 functions independently of Rapamycin by presumably acting on celluar target(s) downstream of the Rapamycin/FKBP12 target, mTOR.

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Standard Handling (A)

Sonstige Hinweise

Tian, Y., et al. 2011. FASEB J.25, 1934.Sarkar, S., et al. 2007. Nat. Chem. Biol.3, 331.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3