06-138
Anti-Cyclin A Antibody
Upstate®, from rabbit
Synonym(e):
Anti-CCN1, Anti-CCNA
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Alle Fotos(2)
About This Item
UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Empfohlene Produkte
Biologische Quelle
rabbit
Qualitätsniveau
Antikörperform
purified immunoglobulin
Antikörper-Produkttyp
primary antibodies
Klon
polyclonal
Speziesreaktivität
rat, sheep, human, mouse
Hersteller/Markenname
Upstate®
Methode(n)
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
Isotyp
IgG
NCBI-Hinterlegungsnummer
UniProt-Hinterlegungsnummer
Versandbedingung
dry ice
Posttranslationale Modifikation Target
unmodified
Angaben zum Gen
human ... CCNA2(890)
Allgemeine Beschreibung
The cell cycle is regulated by the interplay of many molecules. Key among these are the cyclins which are expressed and then degraded in a concerted fashion to drive the stages of the cell cycle. Cyclins combine with cyclin dependent kinases (cdks) to form activated kinases that phosphorylate targets leading to cell cycle regulation. A breakdown in the regulation of this cycle can lead to out of control growth and contribute to tumor formation. Defects in many of the molecules that regulate the cell cycle have been implicated in cancer. Cyclin A is a member of the Cyclin A family that can bind and activate Cdc2 and Cdk2 and is involved in the control of mitosis and S phase. During S phase, cyclin A forms a complex with Cdk2, the pRB-related protein p107 and E2F.
Spezifität
p58cyclin A; does not cross-react with cyclin B or cyclin D2, or 3
Immunogen
peptide corresponding amino acid residues 417-432 (C-KHGVSLLNPPETL-N-L)
Anwendung
Research Category
Epigenetik & nukleäre Funktionen
Epigenetik & nukleäre Funktionen
Research Sub Category
Zellzyklus, DNA-Replikation & -Reparatur
Zellzyklus, DNA-Replikation & -Reparatur
Detect Cyclin A with Anti-Cyclin A Antibody (Rabbit Polyclonal Antibody), that has been shown to work in IP, WB, ICC.
Qualität
routinely evaluated by immunoblot on HeLa nuclear extract
Zielbeschreibung
58kDa
Physikalische Form
Protein G Chromatography
Format: Purified
Lyophilized
Lagerung und Haltbarkeit
2 years at -20°C
Hinweis zur Analyse
Control
Positive Antigen Control: Catalog #12-309, Hela cell nuclear extract. Add an equal volume of Laemmli reducing sample buffer to 10 μL of extract and boil for 5 minutes to reduce the preparation. Load 20 μg of reduced extract per lane for minigels.
Positive Antigen Control: Catalog #12-309, Hela cell nuclear extract. Add an equal volume of Laemmli reducing sample buffer to 10 μL of extract and boil for 5 minutes to reduce the preparation. Load 20 μg of reduced extract per lane for minigels.
Rechtliche Hinweise
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Signalwort
Warning
H-Sätze
Gefahreneinstufungen
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 1
Analysenzertifikate (COA)
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Culture in low levels of oxygen enhances in vitro proliferation potential of satellite cells from old skeletal muscles.
M V Chakravarthy, E E Spangenburg, F W Booth
Cellular and Molecular Life Sciences null
J M Trowbridge et al.
Proceedings of the National Academy of Sciences of the United States of America, 94(19), 10132-10137 (1997-09-18)
We have found that ectopic expression of cyclin A increases hormone-dependent and hormone-independent transcriptional activation by the estrogen receptor in vivo in a number of cell lines, including HeLa cells, U-2 OS osteosarcoma cells and Hs 578Bst breast epithelial cells.
Characterization of the cytoplasmic proline-directed protein kinase in proliferative cells and tissues as a heterodimer comprised of p34cdc2 and p58cyclin A.
Hall, F L, et al.
The Journal of Biological Chemistry, 266, 17430-17440 (1991)
Constitutive overexpression of CDK2 inhibits neuronal differentiation of rat pheochromocytoma PC12 cells
Dobashi, Y., et al
The Journal of Biological Chemistry, 270, 23031-23037 (1995)
Co-purification of p34cdc2/p58cyclin A proline-directed protein kinase and the retinoblastoma tumor susceptibility gene product: interaction of an oncogenic serine/threonine protein kinase with a tumor-suppressor protein.
Williams, R T, et al.
Oncogene, 7, 423-432 (1992)
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