VHL
von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
Synonyme:
HRCA1, RCA1, VHL1, pVHL
Spezies:
Human VHL (7428), Mouse Vhl (22346), Rat Vhl (24874), domestic guinea pig Vhl (100729230), sheep VHL (101122897), cow VHL (540957), domestic cat VHL (101092590), dog VHL (494000), chicken VHL (416117), Zebrafish vhl (791202)
UniProtKB-ID:
Gen-ID:
- Human(7428) Summary: Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
- Mouse(22346) von Hippel-Lindau tumor suppressor
- Rat(24874) von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
- domestic guinea pig(100729230) von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
- sheep(101122897) von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
- cow(540957) von Hippel-Lindau tumor suppressor
- domestic cat(101092590) von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
- dog(494000) von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
- chicken(416117) von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
- Zebrafish(791202) von Hippel-Lindau tumor suppressor
- fruit fly(53433) von Hippel-Lindau
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Anti-VHL Antibody, clone 11E12, clone 11E12, from mouse,
Speziesreaktivität
human, mouse
Anwendung
immunoprecipitation (IP)
western blot
western blot
Anti-Vhl Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Speziesreaktivität
human
Anwendung
immunohistochemistry
Anti-VHL antibody produced in rabbit, affinity isolated antibody,
Speziesreaktivität
human, mouse, rat
Anwendung
ELISA
immunohistochemistry
immunohistochemistry
Monoclonal Anti-VHL antibody produced in mouse, clone 1G12, purified immunoglobulin, buffered aqueous solution,
Speziesreaktivität
human
Anwendung
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Anti-VHL Antibody, clone 1C10 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Speziesreaktivität
human, rat
Anwendung
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Proteins
Produktnummer
Beschreibung
Spezies
VHL Protein Complex, Active, 10 µg, Active complex of five (5) recombinant human enzymes: VHL amino acids 54-end, full length Elongin C, full length Elongin B, full length Cul2, & full length Rbx1. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.,
Spezies
human