TPSAB1
tryptase alpha/beta 1
Synonyme:
TPS1, TPS2, TPSB1
Spezies:
UniProtKB-ID:
Gen-ID:
- Human(7177) Summary: Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]
- Mouse(100503895) tryptase alpha/beta 1
- Rat(54271) tryptase alpha/beta 1
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Antibodies
Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Anti-Mast Cell Tryptase Mouse mAb (AA1), liquid, clone AA1, Calbiochem®,
Speziesreaktivität
canine, feline, human, monkey
Anwendung
Anti-Tryptase Antibody, Mast Cell, clone G3, Alkaline Phosphatase, clone G3, Chemicon®, from mouse,
Speziesreaktivität
human
Anwendung
immunohistochemistry
western blot
western blot
ANTI-TPSAB1 (CENTER) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Speziesreaktivität
human
Anwendung
flow cytometry
western blot
western blot
Anti-TPSB2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Speziesreaktivität
human
Anwendung
immunohistochemistry
western blot
western blot
Anti-TPSAB1 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Speziesreaktivität
human
Anwendung
western blot