SMAD1
SMAD family member 1
Synonyme:
BSP-1, BSP1, JV4-1, JV41, MADH1, MADR1
Spezies:
Human SMAD1 (4086), Mouse Smad1 (17125), Rat Smad1 (25671), dog SMAD1 (475456), domestic cat SMAD1 (101085713), Zebrafish smad1 (30628), chicken SMAD1 (395680), domestic guinea pig Smad1 (100727257), naked mole-rat Smad1 (101725903), sheep SMAD1 (443229) ...Mehr
UniProtKB-ID:
Gen-ID:
- Human(4086) Summary: The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
- Mouse(17125) SMAD family member 1
- Rat(25671) SMAD family member 1
- dog(475456) SMAD family member 1
- domestic cat(101085713) SMAD family member 1
- Zebrafish(30628) MAD homolog 1 (Drosophila)
- chicken(395680) SMAD family member 1
- domestic guinea pig(100727257) SMAD family member 1
- naked mole-rat(101725903) SMAD family member 1
- sheep(443229) SMAD family member 1
- cow(540488) SMAD family member 1
- Horse(100033850) SMAD family member 1
- Domestic Rabbit(100341544) SMAD family member 1
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Antibodies
Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Anti-phospho Smad1/Smad5/Smad8 (Ser463/465)-Antikörper, from rabbit, purified by affinity chromatography,
Speziesreaktivität
xenopus, human, mink, mouse, rat
Anwendung
immunohistochemistry
western blot
western blot
Anti-pSmad1 Ser463/465 Antibody, clone 1N12 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Speziesreaktivität
bovine, canine, chicken, feline, horse, human, monkey, mouse, rat
Anwendung
affinity binding assay
peptide synthesis
western blot
peptide synthesis
western blot
Anti-phospho-Smad1 (Ser463/465) Antibody, Upstate®, from rabbit,
Speziesreaktivität
xenopus, human, mouse, rat
Anwendung
western blot
Anti-SMAD1 Antibody, clone AS22, clone AS22, from mouse,
Speziesreaktivität
human, mouse
Anwendung
immunofluorescence
western blot
western blot
Anti-SMAD1 (Ab-465) antibody produced in rabbit, affinity isolated antibody,
Speziesreaktivität
human, mouse, rat
Anwendung
immunofluorescence
western blot
western blot
Proteins
Produktnummer
Beschreibung
Spezies
SMAD1, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Spezies
human
esiRNA
Produktnummer
Beschreibung
Spezies