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Merck

PIK3CA

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

Synonyme:
CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, p110-alpha
Spezies:
Human PIK3CA (5290), Mouse Pik3ca (18706), Rat Pik3ca (170911), sheep PIK3CA (101110015), chicken PIK3CA (424971), dog PIK3CA (488084), domestic guinea pig Pik3ca (100735084), naked mole-rat Pik3ca (101711934), domestic cat PIK3CA (101097413), cow PIK3CA (282306)
UniProtKB-ID:
P42336, Q14CW1, Q99762
Gen-ID:
  • Human(5290) Summary: Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. [provided by RefSeq, Jul 2008]
  • Mouse(18706) phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
  • Rat(170911) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • sheep(101110015) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • chicken(424971) phosphoinositide-3-kinase, catalytic, alpha polypeptide
  • dog(488084) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • domestic guinea pig(100735084) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • naked mole-rat(101711934) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • domestic cat(101097413) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • cow(282306) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

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Antibodies

Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
SAB5300225
Monoclonal Anti-PIK3CA antibody produced in mouse, clone 4F3, purified immunoglobulin, buffered aqueous solution,
Speziesreaktivität
human
Anwendung
ELISA
flow cytometry
immunofluorescence
western blot
SAB2701957
Anti-PIK3CA antibody produced in rabbit, ,
Speziesreaktivität
human, mouse
Anwendung
immunofluorescence
immunohistochemistry
western blot
AMAB91514
Monoclonal Anti-PIK3CA antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL8347, purified immunoglobulin, buffered aqueous glycerol solution,
Speziesreaktivität
human
Anwendung
immunohistochemistry
SAB5700234
Anti-PIK3CA antibody produced in rabbit, ,
Speziesreaktivität
human, mouse, rat
Anwendung
immunohistochemistry
western blot
ZRB1712
Anti-PI-3 kinase p110α Antibody, clone 1J4 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Speziesreaktivität
human, monkey
Anwendung
affinity binding assay
flow cytometry
immunohistochemistry
western blot

Cell Lines

Produktnummer
Beschreibung
Spezies
CLLS1003
DLD1 Cells PIK3CA +/-, ,
Spezies
human
CLLS1199
MCF10A CELLS PTEN (-/-) PIK3CA H1047R (+/-), ,
Spezies
human

Small Molecule - Inhibitor

Produktnummer
Beschreibung
Spezies
PZ0235
PF-04691502, ≥98% (HPLC),
Spezies
human

Kits

Produktnummer
Beschreibung
Spezies
33-047
PI 3-Kinase 3-step HTRF® Assay, The PI 3-Kinase 3-Step HTRF Assay is a high-performance assay kit that provides a universal method for testing all Class I PI3-Kinases in a homogeneous format.,
Spezies
human
33-04A
PI 3-Kinase 3-step HTRF® Assay, Everything you need to perform the PI3 Kinase 3-step HTRF assays (1920 wells).,
Spezies
human
33-016
PI 3-Kinase HTRF® Assay; 384 wells, The PI 3-Kinase HTRF Assay is a high-performance assay kit that provides a universal method for testing all Class I PI3-Kinases in a homogeneous format. This pack size has a screening capacity of 1 plate.,
Spezies
human
33-017
PI 3-Kinase HTRF® Assay; 1920 wells, The PI 3-Kinase HTRF Assay is a high-performance assay kit that provides a universal method for testing all Class I PI3-Kinases in a homogeneous format. This pack size has a screening capacity of 5 plates.,
Spezies
human
33-036
PI 3-Kinase HTRF® Assay; 10,000 wells, The PI 3-Kinase HTRF Assay is a high-performance assay kit that provides a universal method for testing all Class I PI3-Kinases in a homogeneous format. This pack size has a screening capacity of 10,000 wells.,
Spezies
human

Proteins

Produktnummer
Beschreibung
Spezies
14-602-M
PI3 Kinase (p110α/p85α) Protein, active, 20 µg, Active complex of N-terminal His6-tagged recombinant full-length human p110α & untagged, recombinant, full length, human p85α. For use in Kinase Assays.,
Spezies
human
SRP0233
PI3 kinase (p110a/p85a) Active human, recombinant, expressed in baculovirus infected insect cells, ≥80% (SDS-PAGE),
Spezies
human
14-790-M
PI3 Kinase (p110α/p65α), 10 µg, Complex of N-terminal 6His-tagged, recombinant, full-length Human p110α & untagged, recombinant, full length Human p65α. For use in Kinase Assays.,
Spezies
human
14-783-M
PI3 Kinase (p110α(E545K)/p85α), 10 µg, Complex of N-terminal 6His-tagged, recombinant, full-length human p110α containing the mutation E545K & untagged, recombinant, full-length human p85α. For use in Kinase Assays.,
Spezies
human
14-787-M
PI3 Kinase (p110α (H1047R)/p85α) Murine, 10 µg, Complex of N-terminal 6His-tagged, recombinant, full-length mouse p110α containing the mutation H1047R α & untagged, recombinant, full length mouse p85α. For use in Kinase Assays.,
Spezies
mouse

esiRNA

Produktnummer
Beschreibung
Spezies
EHU231281
MISSION® esiRNA, targeting human PIK3CA (2),
Spezies
human
EHU039391
MISSION® esiRNA, targeting human PIK3CA,
Spezies
human
EMU053821
MISSION® esiRNA, targeting mouse Pik3ca,
Spezies
mouse