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Merck

NR3C2

nuclear receptor subfamily 3, group C, member 2

Synonyme:
MCR, MLR, MR, NR3C2VIT
Spezies:
Human NR3C2 (4306), Mouse Nr3c2 (110784), Rat Nr3c2 (25672), sheep NR3C2 (101107046), cow NR3C2 (280861), cow NR3C2 (537614), domestic cat NR3C2 (101081977), Horse NR3C2 (100062570), dog NR3C2 (475461), chicken NR3C2 (374131) ...Mehr
UniProtKB-ID:
P08235, B0ZBF5, Q2NKL1, Q96KQ8, Q96KQ9
Gen-ID:
  • Human(4306) Summary: This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
  • Mouse(110784) nuclear receptor subfamily 3, group C, member 2
  • Rat(25672) nuclear receptor subfamily 3, group C, member 2
  • sheep(101107046) nuclear receptor subfamily 3, group C, member 2
  • cow(280861) nuclear receptor subfamily 3, group C, member 2
  • cow(537614) nuclear receptor subfamily 3, group C, member 2
  • domestic cat(101081977) nuclear receptor subfamily 3, group C, member 2
  • Horse(100062570) nuclear receptor subfamily 3, group C, member 2
  • dog(475461) nuclear receptor subfamily 3, group C, member 2
  • chicken(374131) nuclear receptor subfamily 3, group C, member 2
  • domestic guinea pig(100735309) nuclear receptor subfamily 3, group C, member 2
  • Zebrafish(562171) nuclear receptor subfamily 3, group C, member 2

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Small Molecule - Agonist

Produktnummer
Beschreibung
Spezies
D7000
11-Deoxycorticosteronacetat, ,
Spezies
human
F6127
Fludrocortisonacetat, ≥98%,
Spezies
human
1174001
11-Deoxycorticosteronacetat, United States Pharmacopeia (USP) Reference Standard,
Spezies
human
D0400000
Desoxycortonacetat, European Pharmacopoeia (EP) Reference Standard,
Spezies
human
1273003
Fludrocortisonacetat, United States Pharmacopeia (USP) Reference Standard,
Spezies
human

Small Molecule - Antagonist

Produktnummer
Beschreibung
Spezies
1619017
Spironolacton-verwandte Verbindung A, United States Pharmacopeia (USP) Reference Standard,
Spezies
human
SML1497
Canrenon, ≥97% (HPLC),
Spezies
human
E6657
Eplerenon, ≥98% (HPLC),
Spezies
human
1619006
Spironolacton, United States Pharmacopeia (USP) Reference Standard,
Spezies
human
BP306
Spironolacton, British Pharmacopoeia (BP) Reference Standard,
Spezies
human

Antibodies

Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
MABS1250
Anti-Mineralocorticoid Receptor Antibody, clone 2D6, clone 2D6, from mouse,
Speziesreaktivität
rat
Anwendung
immunocytochemistry
immunohistochemistry
western blot
AV45599
Anti-NR3C2 antibody produced in rabbit, IgG fraction of antiserum,
Speziesreaktivität
human, rabbit
Anwendung
immunohistochemistry
western blot
HPA074979
Anti-NR3C2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Speziesreaktivität
human
Anwendung
immunofluorescence
SAB2104689
Anti-NR3C2, (N-terminal) antibody produced in rabbit, affinity isolated antibody,
Speziesreaktivität
horse, human
Anwendung
western blot

esiRNA

Produktnummer
Beschreibung
Spezies
EMU201261
MISSION® esiRNA, targeting mouse Nr3c2,
Spezies
mouse
EHU088591
MISSION® esiRNA, targeting human NR3C2,
Spezies
human