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C2300000

Clofibrate

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

2-(4-Chlorophenoxy)-2-methylpropionic acid ethyl ester, Ethyl 2-(4-chlorophenoxy)-2-methylpropionate, Ethyl 2-(4-chlorophenoxy)isobutyrate

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About This Item

Empirical Formula (Hill Notation):
C12H15ClO3
CAS Number:
637-07-0
Molecular Weight:
242.70
Beilstein:
1913459
MDL number:
MFCD00000615
UNSPSC Code:
41116107
PubChem Substance ID:
329774991
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

clofibrate

manufacturer/tradename

EDQM

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1

InChI

1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3

InChI key

KNHUKKLJHYUCFP-UHFFFAOYSA-N

Gene Information

human ... PPARA(5465)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Clofibrate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.
Description
Pricing

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H302,H315,H318,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

113 °C - closed cup

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[Fibrates: mechanism of action, effect on levels of lipids and lipoproteins, risk of coronary events. Part 1. Clofibrate, gemfibrosil, besafibrate].
L M Dobordzhginidze et al.
Kardiologiia, 44(2), 96-103 (2004-05-06)
Clofibrate.
IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, 24, 39-58 (1980-01-01)
Tao Xiong et al.
Indian pediatrics, 49(1), 35-41 (2012-02-10)
To evaluate the effect of clofibrate for unconjugated hyperbilirubinemia in neonates. A systematic review with meta-analysis of randomized controlled trials or quasi-randomized controlled trials was conducted to evaluate the clofibrate treatment in neonates with unconjugated hyperbilirubinemia. We followed the guidelines
Maryam Gholitabar et al.
The Cochrane database of systematic reviews, 12, CD009017-CD009017 (2012-12-14)
There are many pathological conditions leading to an elevated unconjugated bilirubin level (hyperbilirubinaemia) in neonates. Currently the standard therapies for unconjugated hyperbilirubinaemia include phototherapy and exchange transfusion. In addition to phototherapy, clofibrate has been studied as a treatment for hyperbilirubinaemia
G Calais et al.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 22(2), 99-103 (1991-10-01)
It is generally accepted that hypoxia is a common occurrence in many experimental and human tumours and that it is a major cause of local failure after radiotherapy. Many attempts have been made over the last years to eliminate this
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