Cyclodextrin Solubility Table

Table includes the solubility of common cell culture components in water and in a solution of 2-Hydroxylpropyl β-cyclodextrin. Cyclodextrin is a non-toxic compound useful for its ability to solubilize fat soluble vitamins and hormones.

Compound	Solubility in Water (mg/mL)	Solubility in 45% w/v 2-Hydroxylpropyl β-cyclodextrin (mg/mL)	Solubility Enhancement
Acetazolamide	0.7	17	24
6,7-ADTN HBr	0.56	5.6	10
R(–)-N-Allylnorapomorphine HBr	0.3	1.6	5.5
p-Aminoclonidine HCl	0.43	1.4	3.3
(±)-p-Aminoglutethimide	0.16	1.2	7.5
R(+)-Atenolol	<0.01	6	>600
S(–)Atenolol	<0.01	6	>600
Butaclamol	0.25	5.4	21
Chloramphenicol	2.5	53	21
4'-Chlordiazepam	<0.01	1.5	>150
Chlorthalidone	0.12	8	67
CNQX	<0.10	0.8	7.5
Codeine sulfate	3.3	4.3	1.3
CV-1808	<0.07	3.6	54
8-Cylclopentyl-1,3-p-sulfophenylxanthine	<0.20	0.8	4
Dexamethasone	<0.01	24	3000
Diazepam	0.05	5	100
Digoxin	0.07	52	743
7,9-Dimethyluric acid	<0.01	0.4	>36
7,9-Dimethylxanthine	0.75	1.4	1.9
3,5-Dinitrocatechol	0.17	2.8	16.5
1,3-Dipropyl-8-p-sulfophenylxanthine	0.43	6.8	16
DNQX	<0.10	1.9	7.6
(S)-ENBA	<0.09	2.8	>30
Estradiol	<0.01	21	5250
FG-7142	0.07	1.8	27
Furosemide	0.07	1	14
L-Glutamic acid HCl	3.3	8.7	2.6
L-Glutamic acid diethyl ester HCl	3.3	8.7	2.6
Glutethimide	0.26	6	23
Haloperidol	<0.20	0.4	2.3
Hexahydro-sila-difenidol HCl	<0.01	5.7	>570
Hexahydro-sila-difenidol HCl, p-fluoro analog	<1.50	>14	>9.3
Hydrocortisone	0.28	24	86
6-Hydroxydopamine HBr	3.3	5.3	1.6
3-Hydroxymethyl-ß-carboline	<0.20	0.4	2.5
Indomethacin	0.02	3	150
Iodotubercidin	<0.16	0.9	>5.8
Isobutylmethylxanthine	0.3	0.2	10
(–)-MDO-NPA HCl	1.5	4.1	2.7
Methotrexate	0.04	8	178
2-Methylthio ATP	1.5	3.3	2.2
Naltrindole HCl	0.1	2.2	22
Quabain	12.2	61	5
Papaverine HCl	<0.25	4	>16
2-Phenylaminoadenosine	<0.01	3.6	>360
Phenytoin	0.02	7	350
R(–)-PIA	0.3	1.6	5.3
S(+)-PIA	1.2	5	4.2
Pirenperone	<0.19	0.8	>4.1
Prochlorperazine	0.25	2.3	9.2
Progesterone	0.02	39	2600
DL(±)-Propranolol	3.3	8	2.4
(–)-Quisqualic acid	0.52	1.3	2.5
Ranitidine HCl	1.8	7	3.9
Ro 15-4513	<0.01	0.8	>80
Ro 20-1724, PDE inhibitor	<0.01	5	>500
Ro 41-0960, COMT inhibitor	<0.70	1	>1.4
Ryanodine	<0.14	1.3	>9.3
SKF-83566 HCl	<0.01	14	>1400
Spiperone HCl	0.2	2	10
Sulpride	<0.21	8	>38
Testosterone	0.03	30	1154
Tetrahydrocannabinol	<0.01	2	455
Veratridine	<1	>2	>2
Vitamin A	0.01	5	500
Vitamin D	<0.23	8	>35