- Ixodes scapularis: salivary kininase activity is a metallo dipeptidyl carboxypeptidase.
Ixodes scapularis: salivary kininase activity is a metallo dipeptidyl carboxypeptidase.
Experimental parasitology (1998-06-27)
J M Ribeiro, T N Mather
PMID9635445
RÉSUMÉ
Saliva and salivary gland homogenates of Ixodes scapularis contain a dipeptidyl carboxypeptidase activity that accounts for the previously described salivary kininase activity of this tick. Reversed phase HPLC and laser desorption mass spectrography of the reaction products identified bradykinin fragment 1-7 and 1-5 as being produced subsequent to incubation of purified salivary kininase with bradykinin. The activity was inhibited by captopril and EDTA and was activated by cobalt and manganese, a behavior similar to that displayed by angiotensin-converting enzymes of vertebrate and invertebrate origins.
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