- Two new 5-hydroxy-2-pyrone derivatives isolated from a marine-derived fungus Aspergillus flavus.
Two new 5-hydroxy-2-pyrone derivatives isolated from a marine-derived fungus Aspergillus flavus.
The Journal of antibiotics (2008-05-27)
Aiqun Lin, Xiaoming Lu, Yuchun Fang, Tianjiao Zhu, Qianqun Gu, Weiming Zhu
PMID18503205
RÉSUMÉ
Two new compounds, 4-(hydroxymethyl)-5-hydroxy-2H-pyran-2-one (1) and (5-hydroxy-2-oxo-2H-pyran-4-yl) methyl acetate (2), have been isolated from a marine-derived fungus Aspergillus flavus. Their structures were determined by spectroscopic data. Compound 1 induced the production of cAMP on GPR12 transfected CHO and HEK293 cells in a dose-dependent manner, which indicated 1 might be a possible ligand for GPR12.
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Inosine, A metabolite of adenosine that acts as a potent coronary vasodilator. Exhibits a positive inotropic action on heart muscle and can antagonize the ouabain-induced arrhythmias.