- Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta.
Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta.
Science (New York, N.Y.) (1998-05-09)
J Behrens, B A Jerchow, M Würtele, J Grimm, C Asbrand, R Wirtz, M Kühl, D Wedlich, W Birchmeier
PMID9554852
RÉSUMÉ
Control of stability of beta-catenin is central in the wnt signaling pathway. Here, the protein conductin was found to form a complex with both beta-catenin and the tumor suppressor gene product adenomatous polyposis coli (APC). Conductin induced beta-catenin degradation, whereas mutants of conductin that were deficient in complex formation stabilized beta-catenin. Fragments of APC that contained a conductin-binding domain also blocked beta-catenin degradation. Thus, conductin is a component of the multiprotein complex that directs beta-catenin to degradation and is located downstream of APC. In Xenopus embryos, conductin interfered with wnt-induced axis formation.