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SML1220

Doripenem hydrate

≥98% (HPLC), Ultra-broad spectrum carbapenem antibiotic, powder

Synonyme(s) :

(4R,5S,6S)-3-[[(3S,5S)-5-[[(Aminosulfonyl)amino]methyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid hydrate

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A propos de cet article

Formule empirique (notation de Hill) :
C15H24N4O6S2 · H2O
Numéro CAS:
Poids moléculaire :
438.52
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
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Nom du produit

Doripenem hydrate, ≥98% (HPLC)

Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(NC[C@H]1NC[C@H](C1)SC2=C(N3[C@H]([C@H]2C)[C@H](C3=O)[C@H](O)C)C(=O)O)N.O

InChI

1S/C15H24N4O6S2.H2O/c1-6-11-10(7(2)20)14(21)19(11)12(15(22)23)13(6)26-9-3-8(17-5-9)4-18-27(16,24)25;/h6-11,17-18,20H,3-5H2,1-2H3,(H,22,23)(H2,16,24,25);1H2/t6-,7-,8+,9+,10-,11-;/m1./s1

InChI key

NTUBEBXBDGKBTJ-WGLOMNHJSA-N

Biochem/physiol Actions

Doripenem is an ultra-broad spectrum carbopenem antibiotic.
Doripenem is an ultra-broad spectrum carbopenem antibiotic. Doripenem is active against both gram-positive and gram-negative bacteria.
Doripenem hydrate is used to treat complicated urinary infection including Pyelonephritis caused by E.coli. Doripenem hydrate is promoted in the United States as DORIBAX®. This drug is synthesized from p-nitrobenzyl-protected enolphosphate 2b and N-(p-nitrobenzyloxycarbonyl)-protected aminomethylpyrrolidine.

Legal Information

DORIBAX is a registered trademark of Shionogi Inc.

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Cet article
32138F8182CB_88052057
vibrant-m

TEM human cell line

description

≥98% (HPLC)

description

VETRANAL®, analytical standard

description

≥98% (HPLC)

description

88052057, IHW Number: 9057, NOTE: Both the cell line and DNA from the cell line may be available for this product. Please choose -1VL or VIAL for cells, or -DNA-5UG for DNA.

form

powder

form

-

form

powder

form

-

assay

≥98% (HPLC)

assay

-

assay

≥98% (HPLC)

assay

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

-140 to -196°C

solubility

H2O: 5 mg/mL, clear (warmed)

solubility

-

solubility

H2O: ≥20 mg/mL

solubility

-

color

white to beige

color

-

color

white to light brown

color

-


Classe de stockage

11 - Combustible Solids

Que se passe-t-il ?

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable



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Questions

  1. May I enquire on the recommended storage condition of the reconstituted working solution and the estimated shelf life of both the neat and working solution? Is there also a recommended transport temperature for the product?

    1 answer
    1. Unfortunately, the stability of this product upon reconstitution has not been determined. It is recommended to use freshly prepared solutions. This product is shipped at ambient temperature during transport. However, for long-term storage, the powder form is maintained at 2-8°C. Please see the links below to publications reporting the stability of this material in solution:
      https://pubmed.ncbi.nlm.nih.gov/20811032/
      https://pubmed.ncbi.nlm.nih.gov/19108795/

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