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SML0136

TGN-020

≥98% (HPLC), AQP4 inhibitor, powder

Synonyme(s) :

2-(Nicotinamide)-1,3,4-thiadiazole, N-(1,3,4-Thiadiazol-2-yl)-3-pyridinecarboxamide, N-(1,3,4-Thiadiazol-2-yl)pyridine-3-carboxamide, N-(1,3,4-Thiadiazolyl)-m-nicotinamide

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A propos de cet article

Formule empirique (notation de Hill) :
C8H6N4OS
Numéro CAS:
51987-99-6
Poids moléculaire :
206.22
UNSPSC Code:
12352200
PubChem Substance ID:
329825185
NACRES:
NA.77
MDL number:
MFCD00708771
Assay:
≥98% (HPLC)
Form:
powder
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Nom du produit

TGN-020, ≥98% (HPLC)

Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥8 mg/mL

storage temp.

room temp

SMILES string

O=C(Nc1nncs1)c2cccnc2

InChI

1S/C8H6N4OS/c13-7(6-2-1-3-9-4-6)11-8-12-10-5-14-8/h1-5H,(H,11,12,13)

InChI key

AGEGZHOPKZFKBP-UHFFFAOYSA-N

Application

Beas2B human lung epithelial cells were treated with TGN-020 to study the effect on cigarette smoke extracts-induced CCN1 secretion.

Biochem/physiol Actions

Aquaporin 4 (AQP4) inhibitor
TGN-020 is an inhibitor of Aquaporin 4 (AQP4), the most abundant water channel in brain. Aquaporins (AQPs) are water channels required for maintaining fluid homeostasis and enabling water movement across barrier membranes, but can enhance pathological cellular volume changes and cause edema in injury states. Pretreatment with the AQP4 inhibitor TGN-020 significantly reduced the volume of brain edema associated with ischemic injury in a mouse model of focal cerebral ischemia.

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Cet article
SML2472SML1806258881
TGN-020 ≥98% (HPLC)

Sigma-Aldrich

SML0136

TGN-020

UPGL00004 ≥98% (HPLC)

Sigma-Aldrich

SML2472

UPGL00004

YU142670 ≥98% (HPLC)

Sigma-Aldrich

SML1806

YU142670

2-Amino-1,3,4-thiadiazole 97%

Sigma-Aldrich

258881

2-Amino-1,3,4-thiadiazole

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

97%

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

97%

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

storage temp.

room temp

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

solubility

DMSO: ≥8 mg/mL

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

water: soluble 25 mg/mL, clear, colorless

color

white to tan

color

white to pink

color

white to light brown

color

-

Pictogrammes

Exclamation mark
GHS07

Mot-clé

Warning

Codes de danger

H302

Mentions de précaution

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Classe de stockage

11 - Combustible Solids

Que se passe-t-il ?

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Questions

  1. We purchased a quantity of TGN-020 earlier this year but have had exceptional difficulty finding an effective solvent for this compound (tried DCM and H2O). Does Sigma-Aldrich have data on compatible solvents? Primary lit hasn't been helpful. Thanks!

    1 answer

    1. The solubility specification for this product is >/= 8mg/mL in DMSO. The rate may be higher and is lot-specific, however, the minimum concentration in DMSO is 8 mg/mL. A brief literature search shows that HCl, Ethanol, and Dimethylformamide have also been used to dissolve this compound.
      Please see the sample Certificate of Analysis for example:
      https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COFA/Q14/SML0136-5MG0000258843.pdf

      If solubility issues continue, we kindly ask you to navigate to the link https://www.sigmaaldrich.com/techservice, and click on "Report Product Issues" under the Products Section with all the required information so that a member of our team can reach out to you to assist further. Thank you.

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