D4000

trans-Dehydroandrosterone

≥99%

• Synonyme(s) : 3β-Hydroxy-5-androsten-17-one, 5-Androsten-3β-ol-17-one, DHEA, Dehydroepiandrosterone, Dehydroisoandrosterone, Prasterone
• Formule empirique (notation de Hill) : C₁₉H₂₈O₂
• Numéro CAS: 53-43-0
• Poids moléculaire : 288.42
• UNSPSC Code: 51111800
• NACRES: NA.77
• PubChem Substance ID: 24278369
• EC Number: 200-175-5
• Beilstein/REAXYS Number: 2058110
• MDL number: MFCD00003613
• Biological source: synthetic (organic)
• Form: crystalline powder
• Assay: ≥99%

Propriétés

• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥99%
• form: crystalline powder
• drug control: Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada
• mp: 149-151 °C (lit.)
• solubility: chloroform: 50 mg/mL, clear, colorless
• shipped in: ambient
• storage temp.: room temp
• SMILES string: C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@]34C)[C@@H]1CCC2=O
• InChI: 1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1
• InChI key: FMGSKLZLMKYGDP-USOAJAOKSA-N
• Gene Information: human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), SERPINA6(866) ; rat ... Ar(24208)

Description

Biochem/physiol Actions

Dehydroandrosterone (DHEA) is a negative modulator of GABA_A receptors. It is a steroid secreted by the adrenal gland with both estrogenic and androgenic properties. DHEAs conversion to 5-androstenediol, a potent estrogen, enhances the growth and survival of estrogen-sensitive breast tumors.

Negative modulator of GABA_A receptors. Steroid secreted by the adrenal gland with both estrogenic and androgenic properties. Its conversion to 5-androstenediol, a potent estrogen, enhances the growth and survival of estrogen-sensitive breast tumors.

Negative modulator of GABA_A receptors. Steroid secreted by the adrenal gland with both estrogenic and androgenic properties. Its conversion to 5-androstenediol, a potent estrogen, enhances the growth and survival of estrogen-sensitive breast tumors. At high but physiologically valid concentrations, DHEA inhibits proliferation of chromaffin progenitor cells and induces dopaminergic differentiation.

Informations sur la sécurité

• pictograms: GHS08
• signalword: Warning
• hcodes: H361fd
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2
• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves