M-153

Methotrexate-D₃ solution

100 μg/mL in methanol with 0.01N NaOH, ampule of 1 mL, certified reference material, Cerilliant^®

• Formule empirique (notation de Hill) : C₂₀H₁₉N₈O₅D₃
• Numéro CAS: 432545-63-6
• Poids moléculaire : 457.46
• NACRES: NA.24
• UNSPSC Code: 41116107
• EC Number: 200-659-6

Propriétés

• grade: certified reference material
• Quality Segment: 300
• form: liquid
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• concentration: 100 μg/mL in methanol with 0.01N NaOH
• technique(s): gas chromatography (GC): suitable, liquid chromatography (LC): suitable
• application(s): pharmaceutical (small molecule)
• format: single component solution
• storage temp.: −20°C
• SMILES string: [2H]C([2H])([2H])N(Cc1cnc2nc(N)nc(N)c2n1)c3ccc(cc3)C(=O)NC(CCC(O)=O)C(O)=O
• InChI: 1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/i1D3
• InChI key: FBOZXECLQNJBKD-FIBGUPNXSA-N

Description

General description

An internal standard suitable for therapeutic drug monitoring analyses of methotrexate patient serum samples by LC-MS/MS. Used in the treatment of cancer and autoimmune diseases, methotrexate is an antimetabolite and antifolate drug monitored by clinical labs to ensure patients remain within the drug′s therapeutic range. The Snap-N-Spike^® solution format allows laboratories to eliminate weighing operations of hazardous substances such as methotrexate, significantly reducing occupational exposure hazards related to handling of acutely toxic powders, and provides the ability to spike into their matrix of choice just before use.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.

Informations sur la sécurité

• Pictogrammes: GHS02,GHS06,GHS08,GHS05
• Mot-clé: Danger
• Codes de danger: H225,H290,H301 + H311 + H331,H370
• Mentions de précaution: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - Met. Corr. 1 - STOT SE 1
• Organes cibles: Eyes,Central nervous system
• Classe de stockage: 3 - Flammable liquids
• Que se passe-t-il ?: WGK 2
• Point d'éclair (°F): 49.5 °F - closed cup
• Point d'éclair (°C): 9.7 °C - closed cup