V9014

Anti-VMAT2 antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-SLC18A2, Anti-SVAT, Anti-SVMT, Anti-Solute carrier family 18 (vesicular monoamine), member 2, Anti-VAT2, Anti-VMAT2
• MDL number: MFCD02097601
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: mouse, rat, human
• concentration: ~1 mg/mL
• technique(s): immunohistochemistry: 1:100-1:250; western blot: 1:500-1:1,000
• UniProt accession no.: Q05940
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... SLC18A2(6571) ; mouse ... Slc18a2(214084) ; rat ... Slc18a2(25549)

Description

General description

Vesicular monoamine transporter 2 (VMAT2) , also known as solute carrier family 18 member A2 (SLC18A2), is a transmembrane protein that acts at nerve terminals. It is expressed in platelets and in central, peripheral and enteric neurons. The gene encoding VMAT2 consists of 16 exons and is mapped to human chromosome 10q25.

Immunogen

synthetic peptide corresponding an internal sequence of human VMAT2. This sequence is identical in mouse and rat.

Application

Anti-VMAT2 antibody produced in rabbit has also been used in immunofluorescence.

Anti-VMAT2 antibody produced in rabbit has been used in western blot analysis.

Biochem/physiol Actions

Vesicular monoamine transporter 2 (VMAT2) modulates the release of neurotransmitters like dopamine, serotonin and γ-amino butyric acid. It has a role in the accumulation of neurotransmitters in synaptic vesicles to prevent toxicity. VMAT2 has been linked to tardive dyskinesia and may be associated with Parkinson′s disease.

Physical form

solution in phosphate buffered saline, containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves